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      A synergistic mindsets intervention protects adolescents from stress

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          Abstract

          Social-evaluative stressors—experiences in which people feel they could be judged negatively—pose a major threat to adolescent mental health 13 and can cause young people to disengage from stressful pursuits, resulting in missed opportunities to acquire valuable skills. Here we show that replicable benefits for the stress responses of adolescents can be achieved with a short (around 30-min), scalable 'synergistic mindsets' intervention. This intervention, which is a self-administered online training module, synergistically targets both growth mindsets 4 (the idea that intelligence can be developed) and stress-can-be-enhancing mindsets 5 (the idea that one’s physiological stress response can fuel optimal performance). In six double-blind, randomized, controlled experiments that were conducted with secondary and post-secondary students in the United States, the synergistic mindsets intervention improved stress-related cognitions (study 1, n = 2,717; study 2, n = 755), cardiovascular reactivity (study 3, n = 160; study 4, n = 200), daily cortisol levels (study 5, n = 118 students, n = 1,213 observations), psychological well-being (studies 4 and 5), academic success (study 5) and anxiety symptoms during the 2020 COVID-19 lockdowns (study 6, n = 341). Heterogeneity analyses (studies 3, 5 and 6) and a four-cell experiment (study 4) showed that the benefits of the intervention depended on addressing both mindsets—growth and stress—synergistically. Confidence in these conclusions comes from a conservative, Bayesian machine-learning statistical method for detecting heterogeneous effects 6 . Thus, our research has identified a treatment for adolescent stress that could, in principle, be scaled nationally at low cost.

          Abstract

          An online training module that synergistically targets two different mindsets can reduce stress levels in adolescents in the context of social-evaluative stressors—stressful experiences in which individuals fear that others are judging them negatively.

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          Most cited references62

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          A brief measure for assessing generalized anxiety disorder: the GAD-7.

          Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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            Emotion Regulation: Current Status and Future Prospects

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              The ‘Trier Social Stress Test’ – A Tool for Investigating Psychobiological Stress Responses in a Laboratory Setting

              This paper describes a protocol for induction of moderate psychological stress in a laboratory setting and evaluates its effects on physiological responses. The 'Trier Social Stress Test' (TSST) mainly consists of an anticipation period (10 min) and a test period (10 min) in which the subjects have to deliver a free speech and perform mental arithmetic in front of an audience. In six independent studies this protocol has been found to induce considerable changes in the concentration of ACTH, cortisol (serum and saliva), GH, prolactin as well as significant increases in heart rate. As for salivary cortisol levels, the TSST reliably led to 2- to 4-fold elevations above baseline with similar peak cortisol concentrations. Studies are summarized in which TSST-induced cortisol increases elucidated some of the multiple variables contributing to the interindividual variation in adrenocortical stress responses. The results suggest that gender, genetics and nicotine consumption can influence the individual's stress responsiveness to psychological stress while personality traits showed no correlation with cortisol responses to TSST stimulation. From these data we conclude that the TSST can serve as a tool for psychobiological research.
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                Author and article information

                Contributors
                dyeager@utexas.edu
                Christopher.Bryan@mccombs.utexas.edu
                jeremy.jamieson@rochester.edu
                Journal
                Nature
                Nature
                Nature
                Nature Publishing Group UK (London )
                0028-0836
                1476-4687
                6 July 2022
                6 July 2022
                : 1-9
                Affiliations
                [1 ]GRID grid.89336.37, ISNI 0000 0004 1936 9924, Department of Psychology and Behavioral Science and Policy Institute, , University of Texas at Austin, ; Austin, TX USA
                [2 ]GRID grid.89336.37, ISNI 0000 0004 1936 9924, Department of Business, Government, and Society and Behavioral Science and Policy Institute, , University of Texas at Austin, ; Austin, TX USA
                [3 ]GRID grid.168010.e, ISNI 0000000419368956, Department of Psychology, , Stanford University, ; Stanford, CA USA
                [4 ]GRID grid.89336.37, ISNI 0000 0004 1936 9924, Department of Information, Risk and Operations Management, , University of Texas at Austin, ; Austin, TX USA
                [5 ]GRID grid.89336.37, ISNI 0000 0004 1936 9924, Department of Statistics and Data Sciences, , University of Texas at Austin, ; Austin, TX USA
                [6 ]GRID grid.420451.6, ISNI 0000 0004 0635 6729, Empathy Lab, , Google, ; Mountain View, CA USA
                [7 ]GRID grid.16416.34, ISNI 0000 0004 1936 9174, Department of Psychology, , University of Rochester, ; Rochester, NY USA
                Author information
                http://orcid.org/0000-0002-8522-9503
                http://orcid.org/0000-0002-1582-4411
                http://orcid.org/0000-0003-3624-3090
                http://orcid.org/0000-0002-9762-7947
                http://orcid.org/0000-0002-3790-8747
                Article
                4907
                10.1038/s41586-022-04907-7
                9258473
                35794485
                524c45e6-b520-4dde-8ba8-18e9de090277
                © The Author(s) 2022

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 22 May 2021
                : 25 May 2022
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                human behaviour,lifestyle modification
                Uncategorized
                human behaviour, lifestyle modification

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