A dose-finding randomized Phase II study of oral netupitant in combination with palonosetron .75 mg intravenous for the prevention of chemotherapy-induced nausea and vomiting in Japanese patients receiving highly emetogenic chemotherapy.

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Abstract

Netupitant is a novel, selective neurokinin-1 receptor antagonist used for prevention of chemotherapy-induced nausea and vomiting, a distressing side effect of chemotherapy. This double-blind, randomized, Phase II study investigated the dose-response of oral netupitant in Japanese patients receiving highly emetogenic chemotherapy.

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Journal

Journal ID (iso-abbrev): Jpn J Clin Oncol

Title: Japanese journal of clinical oncology

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1465-3621

ISSN (Print): 0368-2811

Publication date (Electronic): Feb 01 2019

Volume: 49

Issue: 2

Affiliations

[1 ] Department of Breast Oncology, Saitama Medical University International Medical Center, Saitama.

[2 ] Division of Breast Oncology, Saitama Cancer Center, Saitama.

[3 ] Department of Thoracic Oncology, Saitama Cancer Center, Saitama.

[4 ] Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Fukuoka.

[5 ] Division of Respiratory Medicine, Gunma Prefectural Cancer Center, Gunma.

[6 ] Department of Thoracic Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo.

[7 ] Division of Pulmonary Medicine, Clinical Department of Internal Medicine, Jichi Medical University Saitama Medical Center, Saitama.

[8 ] Department of Breast and Endocrine Surgery, Tokai University School of Medicine, Kanagawa.

[9 ] Department of Surgery, Tokyo Medical University, Tokyo.

[10 ] Department of Respiratory Medicine and Infectious Disease, Niigata University Medical and Dental Hospital, Niigata.

[11 ] Department of Respiratory Medicine, Saitama Medical University International Medical Center, Saitama.

[12 ] Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo.

[13 ] Thoracic Center, St. Luke's International Hospital, Tokyo, Japan.

Article

Publisher Item ID: 5253755

DOI: 10.1093/jjco/hyy161

PubMed ID: 30576544

SO-VID: 52d0cd0a-ed5d-474f-bd77-83fc49d066d7

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