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      Optimization of parameters for the fabrication of gelatin nanoparticles by the Taguchi robust design method

      , ,

      Journal of Applied Statistics

      Informa UK Limited

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          Most cited references 16

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          Biodegradable nanoparticles for drug and gene delivery to cells and tissue.

          Biodegradable nanoparticles formulated from poly (D,L-lactide-co-glycolide) (PLGA) have been extensively investigated for sustained and targeted/localized delivery of different agents including plasmid DNA, proteins and peptides and low molecular weight compounds. Research about the mechanism of intracellular uptake of nanoparticles, their trafficking and sorting into different intracellular compartments, and the mechanism of enhanced therapeutic efficacy of nanoparticle-encapsulated agent at cellular level is more recent and is the primary focus of the review. Recent studies in our laboratory demonstrated rapid escape of PLGA nanoparticles from the endo-lysosomal compartment into cytosol following their uptake. Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.
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            Design optimization of cutting parameters for turning operations based on the Taguchi method

             W.H. Yang,  Y.S. Tarng (1998)
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              Peroral administration of nanoparticles

               Jörg Kreuter (1991)
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                Author and article information

                Journal
                Journal of Applied Statistics
                Journal of Applied Statistics
                Informa UK Limited
                0266-4763
                1360-0532
                October 10 2008
                December 2008
                October 10 2008
                December 2008
                : 35
                : 12
                : 1345-1353
                10.1080/02664760802382426
                © 2008

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