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      A treatment for Henoch-Schönleinpurpurabased on Shaoyang Channels: a hypothesis and case report

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          Abstract

          Henoch-Schönleinpurpura (HSP) is an IgA-mediated vasculitis which is easy to relapse.A lot of patients have to use glucocorticoids, immunosuppressive drugs and other drugs which will bring sorts of serious side effects.Unfortunately,most of patients have to face the hurt of abdominal pain, arthritis, purpuric rash and renal involvement again after relapse. We have used Xiaochaihudecoration which is a famous formula in Shanghanlun to cure most of patients, especially who with abdominal pain and purpuric rash.Due to the fact that this formula belongs to the Shaoyang Channels, interestingly, we find that these symptoms are located in regions close to the Shaoyang Channels.So that is the reason why Xiaochaihudecoration could work.

          Highlights

          Xiaochaihu Decoration, which is a famous formula in Shanghanlun can regulate Shaoyang Channels and treat abdominal pain and purpuric rash.In addition, symptoms of Henoch-Schönleinpurpura are located in regions close to the Shaoyang Channels.The study proposed that HSP was located throughout the Shaoyang Channels.

          Most cited references5

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          Beneficial effect of Bupleurum polysaccharides on autoimmune disease induced by Campylobacter jejuni in BALB/c mice.

          Zheng Wang, Hong Li, Han Xu … (2009)
          Radix Bupleuri, is one of the most frequently prescribed crude herbs in the prescriptions of traditional Chinese medicine for the treatment of inflammatory diseases and auto-immune diseases. This study was to determine whether the crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium, had beneficial effects on autoimmune disease. BALB/c mice were immunized with CJ-S(131) in Freund's complete adjuvant on day 0, and then boosted on day 14. BPs 15 or 30 mg kg(-1) day(-1), or prednisone 5 mg kg(-1) day(-1) was given to BALB/c mice intragastrically from day 0 to day 34. Treatment with BPs 15 or 30 mg kg(-1) day(-1) for 35 days protected kidney from glomerular injury with reduced immunoglobulin deposition and lowered proteinuria. The increased production of serum autoantibodies and total immunoglobulin G (IgG) was also inhibited. BPs 30 mg kg(-1) day(-1) improved weight loss and spleen swelling when compared with vehicle-treated group. These findings suggested that Bupleurum polysaccharides had a beneficial effect on systemic lupus erythematosus-like syndroma induced by CJ-S(131) in BALB/c mice.
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            Henoch-Schönlein purpura: a review article.

            Donna L. Bratton, T Brinker, Lance Waller … (2007)
            Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. Although HSP is typically a disease of children, adult cases have been described. HSP can affect multiple organs with a characteristic rash present in all patients. Most cases resolve with symptomatic treatment, but serious complications can occur such as renal failure. Primary care physicians should be well aware of the disease because the true incidence is probably underestimated.
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              Henoch-Schönlein purpura

              Frank T Saulsbury (2001)
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                Author and article information

                Contributors
                Xu Rui-Rong
                Journal
                Journal ID (nlm-ta): TMR MOD Herb Med
                Title: TMR Modern Herbal Medicine
                Publisher: TMR Modern Herbal Medicine Editorial Board (Cockle Bay Rd, Auckland, New Zealand )
                ISSN (Electronic): 2537-9798
                Publication date Collection: 25 January 2018
                Publication date (Electronic): 25 January 2018
                Volume: 1
                Issue: 1
                Pages: 35-38
                Affiliations
                [1-2537-9798-1-1-35] 1Department of Hematology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
                Author notes
                *Correspondence to:Rui-RongXu,Department of Hematology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan, China. E-mail: 375134911@ 123456qq.com .
                Article
                Publisher ID: 2537-9798-1-1-35
                DOI: 10.12032/TMRmhm2017B04
                SO-VID: 540b18c2-367a-4416-8150-6bee88c09226
                Copyright statement: Copyright @ 2018
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

                History
                Date received : 15 November 2017
                Date accepted : 10 January 2018
                Funding
                This study was supported by the National Natural Science Foundation of China (No. 81202839), the National Natural Science Foundation of China (No. 81774080), the Natural Science Foundation of Shandong Province (ZR2012HQ023),the Medical science and technology development Foundation of Shandong Province, China (No. 2014WS0431), the Jinan young star of science and technology plan (No. 201406012), and the Affiliated Hospital of Shandong University of Traditional Chinese Medicine and Shandong University, China.
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Medicine,Pharmacology & Pharmaceutical medicine,Health & Social care,Complementary & Alternative medicine
                Keywords: the Shaoyang Channels, Shanghanlun ,Xiaochaihudecoration,Henoch-Schönleinpurpura
                Data availability:
                ScienceOpen disciplines: Medicine, Pharmacology & Pharmaceutical medicine, Health & Social care, Complementary & Alternative medicine
                Keywords: the Shaoyang Channels, Shanghanlun , Xiaochaihudecoration, Henoch-Schönleinpurpura

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