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      High flow nasal therapy in perioperative medicine: from operating room to general ward

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          Abstract

          Background

          High flow nasal therapy (HFNT) is a technique in which humidified and heated gas is delivered to the airways through the nose via small nasal prongs at flows that are higher than the rates generally applied during conventional oxygen therapy. The delivered high flow rates combine mixtures of air and oxygen and enable different inspired oxygen fractions ranging from 0.21 to 1. HFNT is increasingly used in critically ill adult patients, especially hypoxemic patients in different clinical settings.

          Main body

          Noninvasive ventilation delivers positive pressure (end-expiratory and inspiratory pressures or continuous positive airway pressure) via different external interfaces. In contrast, HFNT produces different physiological effects that are only partially linked to the generation of expiratory positive airway pressure. HFNT and noninvasive ventilation (NIV) are interesting non-invasive supports in perioperative medicine. HFNT exhibits some advantages compared to NIV because HFNT is easier to apply and requires a lower nursing workload. Tolerance of HFNT remains a matter of intense debate, and it may be related to selected parameters. Patients receiving HFNT and their respiratory patterns should be closely monitored to avoid delays in intubation despite correct oxygenation parameters.

          Conclusion

          HFNT seems to be an interesting noninvasive support in perioperative medicine. The present review provides anesthesiologists with an overview of current evidence and practical advice on the application of HFNT in perioperative medicine in adult patients.

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          Most cited references65

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          Failure of high-flow nasal cannula therapy may delay intubation and increase mortality.

          Intubation in patients with respiratory failure can be avoided by high-flow nasal cannula (HFNC) use. However, it is unclear whether waiting until HFNC fails, which would delay intubation, has adverse effects. The present retrospective observational study assessed overall ICU mortality and other hospital outcomes of patients who received HFNC therapy that failed.
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            Physiologic Effects of High-Flow Nasal Cannula in Acute Hypoxemic Respiratory Failure.

            High-flow nasal cannula (HFNC) improves the clinical outcomes of nonintubated patients with acute hypoxemic respiratory failure (AHRF).
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              Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation on Reintubation and Postextubation Respiratory Failure in High-Risk Patients: A Randomized Clinical Trial.

              High-flow conditioned oxygen therapy delivered through nasal cannulae and noninvasive mechanical ventilation (NIV) may reduce the need for reintubation. Among the advantages of high-flow oxygen therapy are comfort, availability, lower costs, and additional physiopathological mechanisms.
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                Author and article information

                Contributors
                cortegiania@gmail.com
                giuseppe.accurso86@gmail.com
                terapiadeldolore@lamaddalenanet.it
                antonino.giarratano@unipa.it
                +390916552730 , c.gregoretti@gmail.com
                Journal
                BMC Anesthesiol
                BMC Anesthesiol
                BMC Anesthesiology
                BioMed Central (London )
                1471-2253
                10 November 2018
                10 November 2018
                2018
                : 18
                : 166
                Affiliations
                [1 ]ISNI 0000 0004 1762 5517, GRID grid.10776.37, Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.). Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone, , University of Palermo, ; Via del vespro 129, 90127 Palermo, Italy
                [2 ]ISNI 0000 0004 1762 5517, GRID grid.10776.37, Anesthesia and Intensive Care and Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, ; Palermo, Italy
                Author information
                http://orcid.org/0000-0002-1442-1426
                Article
                623
                10.1186/s12871-018-0623-4
                6230300
                30414608
                559bcbb6-30cf-496a-8ee8-3fa99aa43f5c
                © The Author(s). 2018

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 24 April 2018
                : 19 October 2018
                Categories
                Review
                Custom metadata
                © The Author(s) 2018

                Anesthesiology & Pain management
                high flow nasal therapy,noninvasive ventilation,acute respiratory failure,perioperative medicine

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