Chromosomal imbalances detected in NTRK-rearranged sarcomas by the use of comparative genomic hybridisation.

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Abstract

NTRK-rearranged sarcomas are emerging as a distinct class of sarcomas of particular importance in the era of targeted therapy. The aim of this study was to use array comparative genomic hybridisation (aCGH) to explore the cytogenetic profile of six adult soft tissue sarcomas harbouring NTRK gene fusions.

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Journal

Journal ID (iso-abbrev): Histopathology

Title: Histopathology

Publisher: Wiley

ISSN (Electronic): 1365-2559

ISSN (Print): 0309-0167

Publication date (Electronic): Jun 2021

Volume: 78

Issue: 7

Affiliations

[1 ] Anatomical Pathology, Douglass Hanly Moir Pathology, Macquarie Park, NSW, Australia.

[2 ] Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia.

[3 ] Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.

[4 ] Anatomical Pathology, PathWest, QEII Medical Centre, Nedlands, WA, Australia.

[5 ] School of Medicine, The University of Western Australia, Crawley, WA, Australia.

[6 ] Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.

[7 ] Anatomical Pathology, Clinipath Pathology, Osborne Park, WA, Australia.

[8 ] Chris O'Brien Lifehouse, Sydney, NSW, Australia.

[9 ] Anatomical Pathology, Liverpool Hospital, Liverpool, NSW, Australia.

[10 ] NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia.

Article

DOI: 10.1111/his.14295

PubMed ID: 33128780

SO-VID: 5691ce57-4f08-4cd6-8ab9-cf571f684614

History

Keywords: translocation,sarcoma,chromosomal imbalances, NTRK

Data availability:

Keywords: translocation, sarcoma, chromosomal imbalances, NTRK

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