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      Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates.

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          Abstract

          To mechanistically compare the effects of doxorubicin (DOX) and DOX conjugated with nanodiamonds (Nano-DOX) on human glioblastoma cells (GC).

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          Author and article information

          Journal
          Nanomedicine (Lond)
          Nanomedicine (London, England)
          Future Medicine Ltd
          1748-6963
          1743-5889
          February 2019
          : 14
          : 3
          Affiliations
          [1 ] Department of Pharmacology, School of Basic Medicine, Wuhan University, Donghu Avenue No. 185, Wuhan 430072, China.
          [2 ] Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China.
          [3 ] Demonstration Center for Experimental Basic Medicine Education, School of Basic Medicine, Wuhan University, Donghu Avenue No. 185, Wuhan 430072, China.
          [4 ] Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
          [5 ] Graduate School of Human & Environmental Studies, Kyoto University, Sakyo-Ku, Kyoto 606-8501, Japan.
          [6 ] Department of Ophthalmology, Institute of Ophthalmological Research, Renmin Hospital of Wuhan University, Wuhan 430060, China.
          [7 ] State Key Laboratory of Radiation Medicine & Protection, School of Radiation Medicine & Protection & School for Radiological & Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, China.
          Article
          10.2217/nnm-2018-0330
          30676239
          5693a042-c341-4ba5-bd20-36f9816a58c5
          History

          autophagy,nanodiamonds,apoptosis,glioblastoma cells,HMGB1,doxorubicin

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