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      Correlación entre índice de catabolismo proteico medido por el modelo cinético de la urea y la encuesta dietética en niños con insuficiencia renal crónica en diálisis. Translated title: Correlation between protein catabolism rate measured by kinetic model of urea and dietetic survey in children with chronic renal failure on dialysis

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          Abstract

          Objetivo: Determinar la correlación entre ICP calculado por el modelo cinético de urea y la ingesta proteica determinada mediante encuesta dietética. Material y métodos: En el estudio analítico de correlación, se incluyeron 15 niños con insuficiencia renal crónica (IRC) evaluados en un periodo de un año de seguimiento. Se determinó el ICP mediante la encuesta de Frecuencia de Consumo y recordatorio de 24 h por 3 días y el modelo cinético de la úrea, al inicio y al final del estudio. Se determinó albúmina sérica, urea sérica pre y post recolección de orina en el periodo ínterdialítico y urea en orina del periodo interdialítico. Resultados. El 46,67%(7) fueron del sexo femenino y 53,33%(8) masculino. La edad fue 15 ±2 años. Al inicio, 20% de los pacientes tuvieron niveles de albúmina sérica normales y al final del estudio fue 86,67%. El promedio del ICP calculado al inicio fue 0,993±0,27 y 0,996 ± 0,28 por modelo cinético y encuesta dietética respectivamente y su correlación fue r = 0,9962 y R²= 0,9924. Al final del estudio fue 1,07± 0,28 calculado por la encuesta y de 1,06± 0,27 por el modelo cinético de generación de urea y su correlación fue de r =0,9973 y R²= 0,9924. Conclusión: Existe buena correlación entre el ICP calculado por el modelo cinético de generación de urea y la ingesta proteica determinada por la encuesta dietética (Rev Med Hered 2006;17:77-80).

          Translated abstract

          Objective: To determine correlation between PCR calculated by, kinetic model of urea and the protein ingestion determined by dietetic survey. Material and Methods: Study of correlation analysis. We included 15 children with chronic renal failure (CRF). We calculated PCR by dietetic survey of consumption frequency at last 24h for 3 days and by kinetic model of urea at beginning and finalize of the study. Results: 46.67%(7) were males and 53.33%(8) females. The mean age was 15 ±2 years old. The initial mean PCR measured by urea kinetic model was 0.993±0.27 and 0.996 ± 0.28 by dietetic survey and its correlation was r = 0.9962 and R² = 0.9924. At the end of the study was 1.07± 0.28 and 1.06± 0.27 by dietetic survey and urea kinetic model respectively and its correlation was r = 0.9973 and R² = 0.9924. Serum albumin was normal in 20% of patients at the beginning of study and 86.67% one year after. Conclusion: Good correlation between the PCR calculated by the kinetic model of urea generation and the protein ingestion determined by the dietetic survey exists (Rev Med Hered 2006;17:77-80).

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          Relationship between C-reactive protein, albumin, and cardiovascular disease in patients with chronic kidney disease.

          C-Reactive protein (CRP) level is elevated in kidney failure and may be related to malnutrition and cardiovascular disease (CVD). Data are limited regarding relationships between CRP levels and glomerular filtration rate (GFR), nutritional indices, and CVD in patients with earlier stages of kidney disease. CRP was assayed from samples from the Modification of Diet in Renal Disease (MDRD) Study (n = 801). CRP distributions were compared between the MDRD Study and National Health and Nutrition Examination Survey (NHANES; 1999 to 2000). Associations between CRP level and GFR, nutritional indices, serum albumin levels, and CVD risk factors were examined in the MDRD Study. Geometric means of CRP, adjusted for age and sex, were similar in NHANES (0.23 mg/dL) and the MDRD Study (0.22 mg/dL). In the MDRD Study, CRP level was related directly to measures of body fat and CVD risk factors, inversely with serum albumin level and energy intake, and unrelated to GFR. In multivariable analysis adjusting for other determinants of serum albumin level, high CRP level (>0.6 mg/dL) was associated with a 0.07-g/dL (0.7-g/L; 95% confidence interval [CI], 0.03 to 0.12) lower mean serum albumin level. After adjusting for traditional CVD risk factors, the odds of CVD were 1.73 (95% CI, 1.07 to 2.78) times greater in subjects with a high CRP level. GFR level does not appear to influence CRP level in the earlier stages of chronic kidney disease. CRP levels are independently associated with serum albumin level and CVD prevalence. Inflammation may be involved in the pathophysiological state of malnutrition and CVD in the earlier stages of predominantly nondiabetic kidney disease.
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            Stata statistical software: release 15 College Station

            (2013)
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              Measuring nutritional status in children with chronic kidney disease.

              Children with chronic kidney disease (CKD) are at risk of protein-energy malnutrition. Existing clinical practice guidelines recognize this and recommend specific methods to assess nutritional status in patients with CKD. This review summarizes the methods for nutritional assessment currently recommended in the United States for children with CKD and details the strengths and limitations of these techniques in the clinical setting. Dietary assessment, serum albumin, height, estimated dry weight, weight/height index, upper arm anthropometry, head circumference, and the protein equivalent of nitrogen appearance are reviewed. We also describe methods for body-composition assessment, such as dual-energy X-ray absorptiometry, bioelectrical impedance analysis (BIA), total body potassium, densitometry, and in vivo neutron activation analysis, pointing out some advantages and disadvantages of each. In CKD, fluid overload is the most important factor leading to misinterpretation of nutritional assessment measures. Abnormalities in the distribution of fat and lean tissue may also compromise the interpretation of some anthropometric measures. In addition, metabolic abnormalities may influence the results obtained by some techniques. Issues specific to evaluating nutritional status in the pediatric population are also discussed, including normalization of nutritional measures to body size and sexual maturity. We stress the importance of expressing body-composition measures relative to height in a population in whom short stature is highly prevalent.
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                Author and article information

                Journal
                rmh
                Revista Medica Herediana
                Rev Med Hered
                Universidad Peruana Cayetano Heredia. Facultad de Medicina "Alberto Hurtado" (Lima, , Peru )
                1018-130X
                1729-214X
                April 2006
                : 17
                : 2
                : 77-80
                Affiliations
                [02] orgnameUniversidad Peruana Cayetano Heredia orgdiv1Facultad de Medicina Alberto Hurtado orgdiv2Departamento de Pediatria
                [04] orgnameUniversidad Peruana Cayetano Heredia orgdiv1Facultad de Medicina Alberto Hurtado orgdiv2Departamento de Medicina
                [01] orgnameUniversidad Peruana Cayetano Heredia orgdiv1Servicio de Nefrologia orgdiv2Licenciada de Nutrición y Dietética
                [03] orgnameUniversidad Peruana Cayetano Heredia orgdiv1Facultad de Medicina Alberto Hurtado orgdiv2Departamento de Medicina
                Article
                S1018-130X2006000200004 S1018-130X(06)01700204
                5715756e-bdae-43b7-970b-cbc4f454bbdb

                http://creativecommons.org/licenses/by/4.0/

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                Figures: 0, Tables: 0, Equations: 0, References: 10, Pages: 4
                Product

                SciELO Peru

                Self URI: Texto completo solamente en formato PDF (ES)
                Categories
                Artículos originales

                Insuficiencia renal crónica,children,hemodialysis,protein catabolism rate,Chronic renal failure,niños,diálisis,hemodiálisis,índice de catabolismo proteico

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