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      Delayed presentation of children to the emergency department during the first wave of COVID‐19 pandemic in Italy: Area‐based cohort study

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          Abstract

          Aim

          To ascertain a delay in attendances to the emergency department (ED) during 2020 lockdown.

          Methods

          Area‐based cohort study on paediatric (0‐15 years) attendances resulting in hospital admission in Tuscany, Italy, in February‐May 2020, and the corresponding periods in 2018‐19. We analysed times from symptom onset to arrival, the odds of arriving late (>90th centile of time) and paediatricians’ judgements of a late presentation by logistic models.

          Results

          As expected, ED attendance fell sharply (−62%) in 2020 vs 2018‐19. As for cases studied (455 in 2020 and 1161 in 2018–19), we documented a delay in arrival to the ED in 2020 versus 2018–19 for several groups of diagnoses, namely gastroenteritis, sepsis, wounds, burns and infections overall. Time to presentation over 90th centile was also higher in 2020 (odds ratio, OR: 1.44; 95% confidence interval: 1.00, 2.06), as were paediatricians’ judgements of a late arrival (18.9% of cases in 2020 vs. 13.4% in 2018‐19; OR: 1.58; 1.14, 2.19)

          Conclusion

          In a population‐based cohort, delayed attendances to ED ascertained both subjectively and objectively convey the message to families and to paediatricians to seek hospital care in case of severe or unremitting symptoms and not to wait longer than they normally would.

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          Most cited references21

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          Is Open Access

          Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

          Abstract Aim The coronavirus disease 2019 (COVID‐19) pandemic has affected hundreds of thousands of people. Data on symptoms and prognosis in children are rare. Methods A systematic literature review was carried out to identify papers on COVID‐19, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), using the MEDLINE and Embase databases between January 1 and March 18, 2020. Results The search identified 45 relevant scientific papers and letters. The review showed that children have so far accounted for 1%‐5% of diagnosed COVID‐19 cases, they often have milder disease than adults and deaths have been extremely rare. Diagnostic findings have been similar to adults, with fever and respiratory symptoms being prevalent, but fewer children seem to have developed severe pneumonia. Elevated inflammatory markers were less common in children, and lymphocytopenia seemed rare. Newborn infants have developed symptomatic COVID‐19, but evidence of vertical intrauterine transmission was scarce. Suggested treatment included providing oxygen, inhalations, nutritional support and maintaining fluids and electrolyte balances. Conclusions The coronavirus disease 2019 has occurred in children, but they seemed to have a milder disease course and better prognosis than adults. Deaths were extremely rare.
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            Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

            Abstract Aims To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7–32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3–70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7–6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1–2.8; P = 0.009). Conclusion Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.
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              Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults : A Systematic Review and Meta-analysis

              The degree to which children and adolescents are infected by and transmit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. The role of children and adolescents in transmission of SARS-CoV-2 is dependent on susceptibility, symptoms, viral load, social contact patterns, and behavior.
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                Author and article information

                Contributors
                franca.rusconi@meyer.it , franca.rusconi@ars.toscana.it
                Journal
                Acta Paediatr
                Acta Paediatr
                10.1111/(ISSN)1651-2227
                APA
                Acta Paediatrica (Oslo, Norway : 1992)
                John Wiley and Sons Inc. (Hoboken )
                0803-5253
                1651-2227
                08 July 2021
                October 2021
                08 July 2021
                : 110
                : 10 ( doiID: 10.1111/apa.v110.10 )
                : 2796-2801
                Affiliations
                [ 1 ] Unit of Epidemiology Meyer Children’s University Hospital Florence Italy
                [ 2 ] Unit of Epidemiology Regional Health Agency of Tuscany Florence Italy
                [ 3 ] Quality and Equity Unit Regional Health Agency of Tuscany Florence Italy
                [ 4 ] Department of Emergency Medicine and Trauma Center Meyer Children's University Hospital Florence Italy
                [ 5 ] Division of Neonatology and Pediatrics Versilia Hospital Viareggio Italy
                [ 6 ] Azienda USL Toscana Nord Ovest Pisa Italy
                Author notes
                [*] [* ] Correspondence

                Franca Rusconi, Unit of Epidemiology, Meyer Children’s University Hospital, Viale Pieraccini 24, Florence 50139, Italy.

                Emails: franca.rusconi@ 123456meyer.it ; franca.rusconi@ 123456ars.toscana.it

                Author information
                https://orcid.org/0000-0002-9544-6472
                https://orcid.org/0000-0001-6074-8975
                Article
                APA16019
                10.1111/apa.16019
                8444882
                34214214
                57252d2e-1d64-4ef8-a5bd-485638ba5d08
                ©2021 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd

                This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

                History
                : 24 June 2021
                : 14 March 2021
                : 30 June 2021
                Page count
                Figures: 1, Tables: 2, Pages: 6, Words: 4272
                Categories
                Regular Article
                Regular Articles & Brief Reports
                Covid‐19
                Custom metadata
                2.0
                October 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.7 mode:remove_FC converted:16.09.2021

                Pediatrics
                covid‐19,delayed attendance,emergency medicine,epidemiology,public health
                Pediatrics
                covid‐19, delayed attendance, emergency medicine, epidemiology, public health

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