9
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The autonomic nervous system and hypertension.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Physiological studies have long documented the key role played by the autonomic nervous system in modulating cardiovascular functions and in controlling blood pressure values, both at rest and in response to environmental stimuli. Experimental and clinical investigations have tested the hypothesis that the origin, progression, and outcome of human hypertension are related to dysfunctional autonomic cardiovascular control and especially to abnormal activation of the sympathetic division. Here, we review the recent literature on the adrenergic and vagal abnormalities that have been reported in essential hypertension, with emphasis on their role as promoters and as amplifiers of the high blood pressure state. We also discuss the possible mechanisms underlying these abnormalities and their importance in the development and progression of the structural and functional cardiovascular damage that characterizes hypertension. Finally, we examine the modifications of sympathetic and vagal cardiovascular influences induced by current nonpharmacological and pharmacological interventions aimed at correcting elevations in blood pressure and restoring the normotensive state.

          Related collections

          Author and article information

          Journal
          Circ. Res.
          Circulation research
          1524-4571
          0009-7330
          May 23 2014
          : 114
          : 11
          Affiliations
          [1 ] From the IRCCS Istituto Auxologico Italiano, Milano, Italy (G.M.); Clinica Medica, Dipartimento di Scienze della Salute, Università Milano-Bicocca, Monza (Monza e Brianza), Italy (G.M., G.G.); and IRCCS Multimedica, Sesto San Giovanni, Milano, Italy (G.G.). giuseppe.mancia@unimib.it.
          [2 ] From the IRCCS Istituto Auxologico Italiano, Milano, Italy (G.M.); Clinica Medica, Dipartimento di Scienze della Salute, Università Milano-Bicocca, Monza (Monza e Brianza), Italy (G.M., G.G.); and IRCCS Multimedica, Sesto San Giovanni, Milano, Italy (G.G.).
          Article
          CIRCRESAHA.114.302524
          10.1161/CIRCRESAHA.114.302524
          24855203
          575487f3-38bf-4f39-9d8c-6f7e9db1ddf1
          © 2014 American Heart Association, Inc.
          History

          hypertension,parasympathetic nervous system,sympathetic nervous system

          Comments

          Comment on this article