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      Conservative Management of Suicide Left Ventricle After Surgical Aortic Valve Replacement

      case-report

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          Abstract

          Suicide left ventricle (SLV) remains an underdiagnosed cause of haemodynamic compromise following surgical or transcatheter aortic valve replacement (AVR). Risk factors include female sex and a small left ventricular cavity with asymmetric septal hypertrophy. We present the case of a 63-year-old woman, with a medical history of diabetes mellitus, arterial hypertension and dyslipidaemia who was diagnosed with severe aortic stenosis with normal left ventricular ejection fraction and concentric hypertrophy. She underwent surgical AVR using a bioprosthetic valve, but a few hours after surgery, she developed sudden cardiogenic shock. An urgent transthoracic echocardiogram was performed showing marked systolic anterior motion of the mitral valve resulting in severe dynamic left ventricular outflow tract obstruction and intraventricular gradient. The diagnosis of SLV was made. The patient was managed conservatively with volume loading and oral beta-blockers and her haemodynamic state improved gradually. She was then discharged after favourable evolution. Medical management of SLV includes volume loading to expand the ventricular volume and beta-blockers for their negative inotrope effect. When medical therapy fails, surgical myectomy or alcohol septal ablation can be proposed to remove the obstacle. Some authors have proposed these procedures as prophylactic measures to prevent SLV in high-risk patients.

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          Aortic Stenosis: Pathophysiology, Diagnosis, and Therapy.

          The incidence of aortic stenosis increases with age, affecting up to 10% of the population by the eighth decade. Once symptoms develop, aortic stenosis is rapidly fatal. Proper management requires an understanding of the physiology and criteria used to define disease severity. There is no effective pharmacologic treatment. Surgical aortic valve replacement has been the gold standard treatment for decades. However, over the last 10 years transcatheter aortic valve replacement has emerged as an attractive, less-invasive option for appropriately selected patients. Refinements in valve design and delivery systems have led to widespread use of this breakthrough technology in selected patients. We review the pathophysiology, criteria for valve replacement, and the results of the trials comparing transcatheter aortic valve replacement with surgical aortic valve replacement.
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            Abnormal left ventricular intracavitary flow acceleration in patients undergoing aortic valve replacement for aortic stenosis. A marker for high postoperative morbidity and mortality.

            We examined the clinical and echocardiographic characteristics of patients undergoing aortic valve replacement for aortic stenosis whose continuous wave Doppler studies showed abnormal intracavitary flow acceleration. The clinical and Doppler echocardiographic records of 53 consecutive patients undergoing aortic valve replacement for aortic stenosis were reviewed. Doppler echocardiography was performed at a mean of 6.6 days (range, 0-22 days) after surgery. Thirteen patients (group 1) had a dagger-shaped high-velocity systolic flow signal indicative of abnormal intracavitary flow acceleration on their postoperative Doppler study; group 2 comprised 40 aortic stenosis patients who underwent aortic valve replacement but had no postoperative evidence of abnormal intracavitary flow acceleration. Group 1 postoperative abnormal intracavitary flow velocities ranged from 1.8 to 6.8 m/sec (mean, 4.9 +/- 0.9 m/sec): Resulting dynamic gradients ranged from 10 to 184 mm Hg (mean, 104.6 +/- 32 mm Hg). Compared with group 2, group 1 patients had a distinctive ventricular geometry with more-pronounced hypertrophy, smaller cavities, and higher ejection fraction. Systolic anterior motion of the mitral valve did not accompany abnormal intracavitary flow acceleration in any patient. Six of 13 group 1 patients suffered postoperative hemodynamic compromise characterized by severe hypotension despite adequate pulmonary capillary wedge pressures; group 1 postoperative mortality was significantly greater than that seen in group 2 patients (38% versus 12%, p less than 0.05). Abnormal intracavitary flow acceleration after aortic valve replacement for severe aortic stenosis is associated with a distinctive ventricular geometry and supernormal systolic function but not systolic anterior motion of the mitral valve. Such flow acceleration appears to be a marker for increased postoperative morbidity and mortality. Preoperative and postoperative Doppler echocardiography may be useful in risk stratification and guiding therapy.
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              Abnormal systolic intraventricular flow velocities after valve replacement for aortic stenosis. Mechanisms, predictive factors, and prognostic significance.

              Dynamic intraventricular flow velocities after valve replacement for aortic stenosis have been associated with high in-hospital morbidity and mortality. The aims of the present study were to determine the mechanisms and preoperative predictors of abnormal flow velocity (AFV) after valve replacement for aortic stenosis and to assess the clinical course of patients with AFV after surgery. One hundred consecutive patients with pure aortic stenosis were studied prospectively before operation by cardiac catheterization and Doppler echocardiography. After surgery, intraventricular flow was studied by Doppler echocardiography at rest, during nipride infusion, and during dobutamine infusion. AFV (defined as a systolic dagger-shaped Doppler spectrum > 2 m/s) occurred in 14 patients at rest and in 27 patients during nipride and/or dobutamine infusion. In most patients, AFV was associated with left ventricular cavity squeezing. Left ventricular end-diastolic diameter, preoperative intraventricular flow velocity and septal-to-posterior wall thickness ratio by Doppler echocardiography, and mean transvalvular pressure gradient and ejection fraction by catheterization emerged as predictors of resting postoperative AFV. Patients with resting AFV had a higher incidence of dyspnea or hypotension (64% versus 21%, P < .01) and a longer hospital stay (13.1 +/- 5.8 versus 11.1 +/- 2.5, P < .05) than patients without AFV. In contrast, at a 1-year follow-up, no patient with resting AFV died. First, AFV occurs in 14% of patients at rest after valve replacement for aortic stenosis and can be provoked or worsened by ventricular unloading or inotropic stimulation. Second, AFV is related more frequently to cavity squeezing than to systolic anterior motion of the mitral valve apparatus. Third, a typical pattern (small, hyperdynamic, and asymmetrically hypertrophied ventricle) is predictive for postoperative AFV and should be taken into account for the postoperative management. Finally, the presence of AFV at rest is associated with high in-hospital morbidity but good long-term prognosis.
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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                3 August 2023
                August 2023
                : 15
                : 8
                : e42890
                Affiliations
                [1 ] Cardiology A Department, Ibn Sina Hospital, Mohammed V University, Rabat, MAR
                [2 ] Cardiovascular Surgery B Department, Ibn Sina Hospital, Mohammed V University, Rabat, MAR
                Author notes
                Article
                10.7759/cureus.42890
                10474785
                37664339
                58be3460-2dab-4dae-b8de-5145c1ae7f9f
                Copyright © 2023, Chraibi et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 3 August 2023
                Categories
                Cardiac/Thoracic/Vascular Surgery
                Cardiology

                left ventricular outflow tract obstruction,left ventricular hypertrophy,systolic anterior motion,cardiogenic shock,aortic valve replacement,suicide left ventricle

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