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Abstract
Ageing is today a major societal concern that is intrinsically associated with the
increase of life expectancy. Outside the context of severe degenerative diseases that
affect the elderly populations, normal visible signs of ageing, notably skin sagging
and wrinkles, influence the social and individual perception of peoples. Accordingly,
there is a strong demand for researches on skin ageing. Deciphering the cellular and
molecular processes of skin evolution through ageing is thus an active scientific
domain, at the frontier of tissue developmental and ageing biology. The focus of the
present article is to provide an overview of the current knowledge concerning the
evolution of dermis characteristics at different life stages, from intra-uterine to
post-natal life. The description will integrate stage-specific and age-related changes
in dermis characteristics at the tissue, cell, and molecular levels.