Mice are not little rats :  species differences in a one-day water maze task

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Abstract

The present study examined species differences in spatial and non-spatial memory in the Morris water maze. Male Wistar rats and C57BL/6 mice were tested in a one-day water maze task in which spatial learning, retention, and non-spatial learning were assessed within 3 h. Rats and mice appeared to use different strategies for locating the hidden escape platform. Whereas rats evinced a clear spatial strategy, mice appeared to rely less on spatial cues and more on alternative non-spatial strategies. The sensitivity of this behavioral protocol to subtle species differences highlights the potential use of this one-day water maze task as a tool for evaluating rapidly learning and memory in rodents.

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Most cited references 10

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Developments of a water-maze procedure for studying spatial learning in the rat

Richard Morris (1984)

Developments of an open-field water-maze procedure in which rats learn to escape from opaque water onto a hidden platform are described. These include a procedure (A) for automatically tracking the spatial location of a hooded rat without the use of attached light-emitting diodes; (B) for studying different aspects of spatial memory (e.g. working memory); and (C) for studying non-spatial discrimination learning. The speed with which rats learn these tasks suggests that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function.

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The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.

Joe Tsien, Patricio T. Huerta, Susumu Tonegawa (1996)

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories.

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Of mice and mazes: similarities between mice and rats on dry land but not water mazes.

Ian Whishaw, Jo-Anne Tomie (1996)

Mice are impaired relative to rats in place and matching-to-place learning when tests are given in a swimming pool. The rat advantage may stem from a superior spatial ability or from adaptation to a niche that has prepared them for competency in the water. In the present study, mice (C57BL/6) were compared with rats (Long-Evans) in a number of dry-land spatial tasks given on a radial arm maze and in a place task given in a swimming pool. The performance of the mice matched that of the rats in all dry-land tasks, but was inferior to that of the rats in the swimming pool. The results provide further evidence for a species difference in swimming-pool performance but do not support the idea that there are necessary differences in spatial abilities between mice and rats. It is suggested that, if optimal place learning is required for neurobehavioral studies of mice, such performance is more likely to be obtained in dry-land tasks than in swimming-pool tasks. Nevertheless, the species differences warrant further study because they could provide important insights into species differences is spatial learning more generally.