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Abstract
As functional liquid media, natural deep eutectic solvent (NADES) species can dissolve
natural or synthetic chemicals of low water solubility. Moreover, the special properties
of NADES, such as biodegradability and biocompatibility, suggest that they are alternative
candidates for concepts and applications involving some organic solvents and ionic
liquids. Owing to the growing comprehension of the eutectic mechanisms and the advancing
interest in the natural eutectic phenomenon, many NADES applications have been developed
in the past several years. However, unlike organic solvents, the basic structural
unit of NADES media primarily depends on the intermolecular interactions among their
components. This makes NADES matrices readily influenced by various factors, such
as water content, temperature, and component ratio and, thus, extends the metabolomic
challenge of natural products (NPs). To enhance the understanding of the importance
of NADES in biological systems, this review focuses on NADES properties and applications
in NP research. The present thorough chronological and statistical analysis of existing
report adds to the recognition of the distinctiveness of (NA)DES, involves a discussion
of NADES-related observations in NP research, and reportes applications of these eutectic
mixtures. The work identifies potential areas for future studies of (NA)DES by evaluating
relevant applications, including their use as extraction and chromatographic media
as well as their biomedical relevance. The chemical diversity of natural metabolites
that generate or participate in NADES formation highlights the growing insight that
biosynthetically primordial metabolites (PRIMs) are as essential to the biological
function and bioactivity of unrefined natural products as the biosynthetically more
highly evolutionary metabolites (HEVOs) that can be isolated from crude mixtures.