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      Effects of Dopaminergic Blockade on the Sleep-Associated Changes of Luteinizing Hormone Pulsatility in Early Follicular Phase Women

      , ,

      Neuroendocrinology

      S. Karger AG

      Dopamine, Sleep, LH pulses

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          Abstract

          To investigate the dopaminergic role in the sleep-associated changes of luteinizing hormone (LH) pulsatile pattern, 11 normal cycling women were studied in the early follicular phase (EF, days 3 and 4) of their cycles before and after the administration of metoclopramide (MCP), a dopamine receptor antagonist. Twenty-four-hour infusions of either saline (NaCl 150 mmol/l–50 ml/h) or metoclopramide (MCP, 30 µg/kg/h) were conducted in a random sequence. Pulsatile LH activities were assessed in blood samples obtained at 15-min intervals for 48 h. Sleep was electrophysiologically confirmed by EEG during night hours (23.00–07.00 h). Significant sleep-associated decreases in LH pulse frequency (p < 0.05) and mean LH serum levels (p < 0.001) with a concurrent increase in LH pulse amplitude (p < 0.01) were observed during the saline control studies. MCP infusion failed to significantly modify the LH pulsatile activity during either the wake or sleep periods. In particular, it did not prevent the changes in LH pulsatility during sleep. This observation suggests that a dopaminergic mechanism does not critically contribute to the sleep-related changes in LH pulsatile activity in women during the early follicular phase.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1988
          1988
          02 April 2008
          : 48
          : 6
          : 634-639
          Affiliations
          Department of Reproductive Medicine, School of Medicine (T-002), and General Clinical Research Center, University of California, San Diego, La Jolla, Calif., USA
          Article
          125074 Neuroendocrinology 1988;48:634–639
          10.1159/000125074
          3251162
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 6
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          Original Paper

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