Zhenwei Su: Role: InvestigationRole: MethodologyRole: VisualizationRole: Writing – original draftRole:
Writing – review & editing
Jonathan Brooks: Role: InvestigationRole: MethodologyRole: VisualizationRole: Writing – review & editing
Jeffrey Pelker: Role: InvestigationRole: MethodologyRole: VisualizationRole: Writing – review & editing
Tatyana Andreyeva: Role: InvestigationRole: MethodologyRole: VisualizationRole: Writing – review & editing
Hanna Sobon: Role: InvestigationRole: VisualizationRole: Writing – review & editing
Roger Gifford: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Matthew Powers: Role: Formal analysisRole: InvestigationRole: VisualizationRole: Writing – review
& editing
Jing Wang: Role: InvestigationRole: ValidationRole: VisualizationRole: Writing – review & editing
Corey Dower: Role: Formal analysisRole: InvestigationRole: ValidationRole: Writing – review & editing
Martin Hegen:
ORCID: https://orcid.org/0000-0002-0883-9076
Role: ConceptualizationRole: MethodologyRole: SupervisionRole: Writing – review &
editing
Dean Messing: Role: ConceptualizationRole: Project administrationRole: SupervisionRole: ValidationRole:
Writing – review & editing
Alfredo Darmanin Sheehan: Role: ConceptualizationRole: Project administrationRole: SupervisionRole: ValidationRole:
Writing – review & editing
Joseph J. Brennan:
ORCID: https://orcid.org/0000-0002-8939-1583
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Project administrationRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing – original draftRole:
Writing – review & editing
Slava Rom: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
20
January
2023
Publication date Collection: 2023
Volume: 18
Issue: 1
Electronic Location Identifier: e0280590
Affiliations
[1
]
BioMedicine Design, Pfizer, Cambridge, Massachusetts, United States of America
[2
]
Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America
[3
]
BioMedicine Design, Pfizer, Dublin, Ireland
Lewis Katz School of Medicine, Temple University, UNITED STATES
Author notes
Competing Interests: All authors were employees of Pfizer during this work. Pfizer provided support in
the form of salaries for the following authors: ZS, JB, JP, TA, HS, RG, MP, JW, CD,
MH, DM, ADS, JJB). HS is currently an employee of Beam Therapeutics. MP is currently
an employee at Sony Biotechnology. The following authors are Pfizer shareholders (JB,
JP, TA, RG, JW, MH, DM, ADS, JJB). There are no patents, products in development,
nor marketed products associated with this research to declare. This does not alter
our adherence to PLOS ONE policies on sharing data and materials.
[¤a]
Current address: Beam Therapeutics, Cambridge, Massachusetts, United States of America
[¤b]
Current address: Sony Biotechnology Inc, San Jose, California, United States of America
Author information
Article
Publisher ID:
PONE-D-22-28236
DOI: 10.1371/journal.pone.0280590
PMC ID: 9858354
PubMed ID: 36662882
SO-VID: 5c3e3a24-82b8-4f3e-952a-24659340f4ab
Copyright © © 2023 Su et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/100004319, Pfizer;
Pfizer Inc. provided support for this research in the form of research materials and
salaries of the authors. Pfizer had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
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