Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC
      DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology
      for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes,
      and Pancreatic Cancer

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Abstract

Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis, but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes is clinically significant; however, currently there is no validated method to differentiate these diabetes subtypes. We describe a study, “Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study,” which seeks to address this knowledge gap. The DETECT study is a multicenter study that will examine differences in hormone and glucose excursions following a mixed meal test. The study will also create a biorepository that will be used to evaluate novel diagnostic biomarkers for differentiating these diabetes subtypes.

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Journal

Journal ID (nlm-journal-id): 8608542

Journal ID (pubmed-jr-id): 6627

Journal ID (nlm-ta): Pancreas

Journal ID (iso-abbrev): Pancreas

Title: Pancreas

ISSN (Print): 0885-3177

ISSN (Electronic): 1536-4828

Publication date Nihms-submitted: 28 August 2018

Publication date (Print): Nov-Dec 2018

Publication date PMC-release: 01 November 2019

Volume: 47

Issue: 10

Pages: 1239-1243

Affiliations

[* ]Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH

[† ]Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

[‡ ]Division of Endocrinology & Metabolism, Indiana University School of Medicine, Indianapolis IN

[§ ]Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX

[‖ ]Department of Neurology, University of Toledo, College of Medicine, Toledo, OH

[¶ ]Section of Endocrinology, Diabetes and Metabolism, Baylor College of Medicine, Houston, TX

[# ]Departments of Pediatrics and Surgery, University of Minnesota Medical School, Minneapolis, MN

[** ]Diabetes and Metabolism Research Center, Division of Endocrinology, Diabetes & Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH

[§ ]Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX

[†† ]Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA

[‡‡ ]Departments of Medicine, and Biochemistry and Molecular Biology, Indiana University School of Medicine, the Melvin and Bren Simon Cancer Center, and the Pancreatic Cancer Signature Center, Indianapolis, IN

[§§ ]Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, MN

[‖‖ ]Department of Surgery, University of Auckland, Auckland, New Zealand

[¶¶ ]Departments of Medicine, Cell Biology & Molecular Physiology, and Department of Human Genetics, University of Pittsburgh, and UPMC, Pittsburgh, PA

[## ]Division of Gastroenterology & Hepatology, University of Pittsburgh Medical Center, Pittsburgh, PA

[§ ]Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX

[*** ]Cancer Biomarker Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD

[† ]Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD

[††† ]Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA

Author notes

Address correspondence to: Phil A. Hart, MD, Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, 410 West Tenth Avenue, Columbus, OH 43210 ( philip.hart@ 123456osumc.edu ). Phone: 614-366-6213, Fax: 614-293-8518

Article

Accession ID: PMC6195331 Pmcid ID: PMC6195331 Pmc-uid ID: 6195331 Manuscript ID: nihpa1505050

DOI: 10.1097/MPA.0000000000001168

PMC ID: 6195331

PubMed ID: 30325863

SO-VID: 5c7ad0c5-989a-4806-bd17-07381b7d7ee3

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Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: Rationale and Methodology for the DETECT Study From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

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