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      High transvalvular pressure gradients on intraoperative transesophageal echocardiography after aortic valve replacement: what does it mean?

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          Abstract

          Intraoperative transesophageal echocardiography is now used routinely during aortic valve replacement, allowing immediate evaluation of replaced or repaired valves. It is well recognised that high transvalvular pressure gradients can be detected immediately after implantation of a prosthetic aortic valve which may be due to multifactorial confounding variables, including functional phenomena, pressure recovery and prosthesis-patient mismatch. This review article explores the variety of methods available for assessing prosthetic aortic valve function and considers causative factors which may contribute to high transvalvular gradients in an attempt to determine whether a physical problem with the valve exists, or whether the valve is functioning normally.

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          The problem of valve prosthesis-patient mismatch.

          Valve prostheses have played an important part in the past two decades in the management of patients with valvular heart disease. However, many of the devices used in valve replacement have introduced new clinical problems. This paper deals with some of the problems associated with valve replacement, including one not previously emphasized--valve prosthesis-patient mismatch, which may cause obstruction to ventricular outflow and/or inflow.
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            Prosthesis-patient mismatch: definition, clinical impact, and prevention.

            Prosthesis-patient mismatch (PPM) is present when the effective orifice area of the inserted prosthetic valve is too small in relation to body size. Its main haemodynamic consequence is to generate higher than expected gradients through normally functioning prosthetic valves. This review updates the present knowledge about the impact of PPM on clinical outcomes. PPM is common (20-70% of aortic valve replacements) and has been shown to be associated with worse haemodynamic function, less regression of left ventricular hypertrophy, more cardiac events, and lower survival. Moreover, as opposed to most other risk factors, PPM can largely be prevented by using a prospective strategy at the time of operation.
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              Hemodynamic and clinical impact of prosthesis-patient mismatch in the aortic valve position and its prevention.

              Prosthesis-patient mismatch is present when the effective orifice area of the inserted prosthetic valve is less than that of a normal human valve. This is a frequent problem in patients undergoing aortic valve replacement, and its main hemodynamic consequence is the generation of high transvalvular gradients through normally functioning prosthetic valves. The purposes of this report are to present an update on the concept of aortic prosthesis-patient mismatch and to review the present knowledge with regard to its impact on hemodynamic status, functional capacity, morbidity and mortality. Also, we propose a simple approach for the prevention and clinical management of this phenomenon because it can be largely avoided if certain simple factors are taken into consideration before the operation.
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                Author and article information

                Journal
                HSR Proc Intensive Care Cardiovasc Anesth
                HSR Proc Intensive Care Cardiovasc Anesth
                2037-0504
                hsrp
                HSR Proceedings in Intensive Care & Cardiovascular Anesthesia
                EDIMES Edizioni Internazionali Srl
                2037-0504
                2037-0512
                2009
                : 1
                : 4
                : 7-18
                Affiliations
                Department of Anaesthesia, Glenfield Hospital, University Hospitals of Leicester NHS Trust, United Kingdom
                Author notes
                Dr. Justiaan Swanevelder MBChB, MMed (Anaes), FCA (SA), FRCA Glenfield Hospital University Hospitals of Leicester NHS Trust, Groby Road, Leicester, LE3 9QP, United Kingdom; E-mail: justiaan.swanevelder@ 123456uhl-tr.nhs.uk
                Article
                200904007
                3484557
                23439238
                5ceba90f-2c62-4427-95b7-e364d235a3f9
                Copyright © 2009, HSR Proceedings in Intensive Care and Cardiovascular Anesthesia

                This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License 3.0, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode.

                History
                Categories
                Review-Article

                transesophageal echocardiography,cardiac surgery,aortic valve replacement,prosthetic aortic valve

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