Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide

Abstract

Clozapine remains the only drug treatment likely to benefit patients with treatment resistant schizophrenia. Its use is complicated by an increased risk of neutropenia and so there are stringent monitoring requirements and restrictions in those with previous neutropenia from any cause or from clozapine in particular. Despite these difficulties clozapine may yet be used following neutropenia, albeit with caution. Having had involvement with 14 cases of clozapine use in these circumstances we set out our approach to the assessment of risks and benefits, risk mitigation and monitoring with a practical guide.

Contributors

Edward Silva: [e-mail]

Journal

Journal ID (nlm-ta): BMC Psychiatry

Journal ID (iso-abbrev): BMC Psychiatry

Title: BMC Psychiatry

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-244X

Publication date (Electronic): 5 June 2020

Publication date PMC-release: 5 June 2020

Publication date Collection: 2020

Volume: 20

Affiliations

[1 ]GRID grid.439410.b, ISNI 0000 0000 8608 0320, Consultant Forensic Psychiatrist, , Ashworth Hospital, Mersey Care NHS Foundation Trust, ; Parkbourn, Maghull, Merseyside, L31 1HW UK

[2 ]GRID grid.439372.8, ISNI 0000 0004 0641 7667, Consultant Haematologist, , Arrowe Park Hospital, ; Arrowe Park Road, Upton, Merseyside, Wirral CH49 5PE UK

Article

Publisher ID: 2592

DOI: 10.1186/s12888-020-02592-2

PMC ID: 7275543

PubMed ID: 32503471

Copyright statement: © The Author(s) 2020

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Categories

Subject: Review

Custom metadata

issue-copyright-statement © The Author(s) 2020