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      M-7 Lowers Rabbit Intraocular Pressure

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          Abstract

          Changes in intraocular pressure (IOP) and pupil diameter were studied in albino rabbits following topical administration of TL-99, M-7 (NN-dimethyl analogues of 2-aminotetralin), DiPr-5,6-ADTN, DiPr-6,7-ADTN (dipropyl analogues of aminotetralin) and DPDA (NN-di-n-propyl-dopamine), known as mixed α-adrenoceptor/dopamine receptor agonists with variable α<sub>1</sub>/α<sub>2</sub>-adrenoceptor selectivity. The potencies of those compounds to decrease IOP were compared with each other. We found that M-7 has the most potent IOP-lowering properties, caused minimal ocular discomfort and is of interest as a potential antiglaucoma agent. The ocular hypotension was completely inhibited by rauwolscine and slightly antagonized by various other blocking agents. The results strongly suggest that the IOP-lowering effect of M-7 is mediated by the stimulation of α2-adrenoceptors.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1985
          1985
          04 December 2009
          : 17
          : 6
          : 362-372
          Affiliations
          aThe Netherlands Ophthalmic Research Institute, Biochemical Laboratory, and bDepartment of Experimental Ophthalmology, Amsterdam; cUniversity of Amsterdam, Division of Pharmacotherapy, Amsterdam, The Netherlands
          Article
          265402 Ophthalmic Res 1985;17:362–372
          10.1159/000265402
          4069574
          60157d61-a491-493c-ab5c-546bca56f51e
          © 1985 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 06 February 1985
          : 26 February 1985
          Page count
          Pages: 11
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          β1/β2-Adrenoceptor agonists,α1/α2-Adrenoceptor agonists,Dopamine agonists,M-7,Conscious rabbit,2-Aminotetralins,Intraocular pressure

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