A population pharmacokinetic model based on HPTN 077 of long-acting injectable cabotegravir for HIV PrEP.

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Abstract

Cabotegravir delivered as a long-acting intramuscular injection has shown superior efficacy to oral tenofovir-emtricitabine as pre-exposure prophylaxis (PrEP) for HIV. Cabotegravir pharmacokinetics (PK), like those of other long-acting depot preparations, exhibit variability between individuals and between injection occasions. The aim of this study is to describe the population pharmacokinetics of long-acting cabotegravir (CAB-LA).

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Author and article information

Journal

Journal ID (iso-abbrev): Br J Clin Pharmacol

Title: British journal of clinical pharmacology

Publisher: Wiley

ISSN (Electronic): 1365-2125

ISSN (Print): 0306-5251

Publication date (Electronic): Oct 2022

Volume: 88

Issue: 10

Affiliations

[1 ] School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.

[2 ] Department of Medicine, Division of Clinical Pharmacology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

[3 ] Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

[4 ] Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

[5 ] Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

[6 ] Los Angeles, Center for Clinical AIDS Research and Education, The University of California, Los Angeles, CA, USA.

[7 ] FHI 360, Durham, NC, USA.

[8 ] GlaxoSmithKline, Research Triangle Park, NC, USA.

[9 ] Department of Medicine, Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Article

Mid ID: NIHMS1874649

DOI: 10.1111/bcp.15477

PMC ID: 10077525

PubMed ID: 35949044

SO-VID: 6070da94-f386-4732-86d7-9cbe755ed7a6

History

Keywords: pharmacometrics,infectious diseases,antiretrovirals,HIV/AIDS

Data availability:

Keywords: pharmacometrics, infectious diseases, antiretrovirals, HIV/AIDS

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