Low vitamin K1 intake in haemodialysis patients.

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Abstract

Vitamin K acts as a coenzyme in the γ-carboxylation of vitamin K-dependent proteins, including coagulation factors, osteocalcin, matrix Gla protein (MGP), and the growth arrest-specific 6 (GAS6) protein. Osteocalcin is a key factor for bone matrix formation. MGP is a local inhibitor of soft tissue calcification. GAS6 activity prevents the apoptosis of vascular smooth muscle cells. Few data on vitamin K intake in chronic kidney disease patients and no data in patients on a Mediterranean diet are available. In the present study, we evaluate the dietary intake of vitamin K1 in a cohort of patients undergoing haemodialysis.

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Journal

Journal ID (iso-abbrev): Clin Nutr

Title: Clinical nutrition (Edinburgh, Scotland)

Publisher: Elsevier BV

ISSN (Electronic): 1532-1983

ISSN (Print): 0261-5614

Publication date (Electronic): Apr 2017

Volume: 36

Issue: 2

Affiliations

[1 ] National Research Council (CNR) - Institute of Clinical Physiology (IFC), Pisa, Italy; Department of Medicine, University of Padua, Italy. Electronic address: dante.lucia@libero.it.

[2 ] Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

[3 ] National Research Council (CNR), Neuroscience Institute, Padua, Italy.

[4 ] Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, CNR, Institute of Biomedicine, Reggio Calabria, Calabria, Italy.

[5 ] Laboratory Medicine Unit, Department of Medicine, University of Padua, Italy.

[6 ] Department of Medicine (DI-MED), Geriatric Section, University of Padua, Italy.

[7 ] National Research Council (CNR) - Institute of Clinical Physiology (IFC), Pisa, Italy; Department of Medicine, University of Padua, Italy.

[8 ] Department of Medicine, Clinica Medica 1, University of Padova, Padova, Italy.

[9 ] Rheumatology Unit, Department of Medicine, University of Verona, Italy.

[10 ] Nephrology Unit, ULSS 1 Belluno, Italy.

[11 ] UOC Nephrology and Dialysis, ULSS 13, Dolo, Italy.

[12 ] UOC Nephrology and Dialysis, ULSS 2, Feltre, Italy.

[13 ] Nephrology Unit, University of Padua, Padua, Italy.

[14 ] Renal Unit, IRCCS Multimedica, Sesto San Giovanni, Milan, Italy.

[15 ] Nephrology and Dialysis Unit, Ospedale San Carlo Borromeo, ASST Santi Paolo e Carlo, Milan, Italy; Department of Clinical and Biomedical Sciences "Luigi Sacco", University of Milano, Italy.

Article

Publisher Item ID: S0261-5614(16)30070-X

DOI: 10.1016/j.clnu.2016.04.024

PubMed ID: 27234935

SO-VID: 60c90645-aea7-42c5-817d-5d97465e8433

History

Keywords: Dialysis,Diet,Haemodialysis,Menaquinone,Nutrition,Phylloquinone

Data availability:

Keywords: Dialysis, Diet, Haemodialysis, Menaquinone, Nutrition, Phylloquinone

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