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      Evaluation of Palm Oil as a Suitable Vegetable Oil for Vitamin A Fortification Programs

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          Abstract

          Fortification programs are considered to be an effective strategy to mitigate vitamin A deficiency in populations at risk. Fortified vegetable oils rich in polyunsaturated fatty acids were shown to be prone to oxidation, leading to limited vitamin A stability. Thus, it was hypothesized that fortified oils consisting of mainly saturated fatty acids might enhance the stability of vitamin A. Mildly (peroxide value: 1.0 meq O 2/kg) and highly (peroxide value: 7.5 meq O 2/kg) oxidized palm oil was stored, after fortification with 60 International Units/g retinyl palmitate, in 0.5 L transparent polyethylene terephthalate bottles under cold fluorescent lighting (12 h/day) at 32 °C for 57 days. An increase of the peroxide value by 15 meq O 2/kg, which was also reflected by a decrease of α-tocopherol congener by 15%–18%, was determined independent of the initial rancidity. The oxidative deterioration of the highly oxidized palm oil during storage was correlated with a significant 46% decline of the vitamin A content. However, household storage of mildly oxidized palm oil for two months did not induce any losses of vitamin A. Thus, mildly oxidized palm oil may be recommended for vitamin A fortification programs, when other sources of essential fatty acids are available.

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          Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases.

          B. N. Ames (1983)
          The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body's defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.
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            Predicting the activity of phenolic antioxidants: theoretical method, analysis of substituent effects, and application to major families of antioxidants.

            A procedure based on density functional theory is used for the calculation of the gas-phase bond dissociation enthalpy (BDE) and ionization potential for molecules belonging to the class of phenolic antioxidants. We show that use of locally dense basis sets (LDBS) vs full basis sets gives very similar results for monosubstituted phenols, and that the LDBS procedure gives good agreement with the change in experimental BDE values for highly substituted phenols in benzene solvent. Procedures for estimating the O--H BDE based on group additivity rules are given and tested. Several interesting classes of phenolic antioxidants are studied with these methods, including commercial antioxidants used as food additives, compounds related to Vitamin E, flavonoids in tea, aminophenols, stilbenes related to resveratrol, and sterically hindered phenols. On the basis of these results we are able to interpret relative rates for the reaction of antioxidants with free radicals, including a comparison of both H-atom-transfer and single-electron-transfer mechanisms, and conclude that in most cases H-atom transfer will be dominant.
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              The anemia of vitamin A deficiency: epidemiology and pathogenesis.

              To gain insight into vitamin A deficiency as a cause of anemia. Comprehensive review of the scientific literature. Although vitamin A deficiency is recognized to cause anemia, 'vitamin A deficiency anemia' lacks complete characterization as a distinct clinical entity. Vitamin A appears to be involved in the pathogenesis of anemia through diverse biological mechanisms, such as the enhancement of growth and differentiation of erythrocyte progenitor cells, potentiation of immunity to infection and reduction of the anemia of infection, and mobilization of iron stores from tissues. Epidemiological surveys show that the prevalence of anemia is high in populations affected by vitamin A deficiency in developing countries. Improvement of vitamin A status has generally been shown to reduce anemia, but the actual public health impact on anemia is unclear. Further work is needed to elucidate the biological mechanisms by which vitamin A causes anemia. The inclusion of anemia as an outcome measure in future micronutrient intervention studies should help provide further insight into the anemia of vitamin A deficiency.
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                Author and article information

                Journal
                Nutrients
                Nutrients
                nutrients
                Nutrients
                MDPI
                2072-6643
                21 June 2016
                June 2016
                : 8
                : 6
                : 378
                Affiliations
                [1 ]Department of Nutritional and Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria; hernler.natalie@ 123456gmail.com (N.H.); mathias.zaunschirm@ 123456univie.ac.at (M.Z.); Julia.Kienesberger@ 123456gmx.at (J.K.); veronika.somoza@ 123456univie.ac.at (V.S.)
                [2 ]Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria; mark.somoza@ 123456univie.ac.at
                [3 ]Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; klaus.kraemer@ 123456sightandlife.org
                [4 ]Sight and Life, Kaiseraugst 4303, Switzerland
                Author notes
                [* ]Correspondence: marc.pignitter@ 123456univie.ac.at ; Tel.: +43-1-4277-70621
                Article
                nutrients-08-00378
                10.3390/nu8060378
                4924219
                27338464
                617ec8fd-36e5-4a71-b3cb-e1322eb4d783
                © 2016 by the authors; licensee MDPI, Basel, Switzerland.

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 11 March 2016
                : 16 June 2016
                Categories
                Article

                Nutrition & Dietetics
                palm oil,lipid oxidation,vitamin a,vitamin e,hexanal
                Nutrition & Dietetics
                palm oil, lipid oxidation, vitamin a, vitamin e, hexanal

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