Disrupted default mode network connectivity in migraine without aura

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Abstract

Background

Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated disrupted default mode network (DMN) connectivity in a number of pain conditions, including migraine. However, the significance of altered resting-state brain functional connectivity in migraine is still unknown. The present study is aimed to explore DMN functional connectivity in patients with migraine without aura (MwoA) and investigate its clinical significance.

Methods

To calculate and compare the resting-state functional connectivity of the DMN in 20 patients with MwoA, during the interictal period, and 20 gender- and age-matched HC, Brain Voyager QX was used. Voxel-based morphometry was used to assess whether between-group differences in DMN functional connectivity were related to structural differences. Secondary analyses explored associations between DMN functional connectivity, clinical and neuropsychological features of migraineurs.

Results

In comparison to HC, patients with MwoA showed decreased connectivity in prefrontal and temporal regions of the DMN. Functional abnormalities were unrelated to detectable structural abnormalities or clinical and neuropsychological features of migraineurs.

Conclusions

Our study provides further evidence of disrupted DMN connectivity in patients with MwoA. We hypothesize that a DMN dysfunction may be related to behavioural processes such as a maladaptive response to stress which seems to characterize patients with migraine.

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Most cited references 26

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Electrophysiological signatures of resting state networks in the human brain.

D. Mantini, M G Perrucci, C Del Gratta … (2007)

Functional neuroimaging and electrophysiological studies have documented a dynamic baseline of intrinsic (not stimulus- or task-evoked) brain activity during resting wakefulness. This baseline is characterized by slow (<0.1 Hz) fluctuations of functional imaging signals that are topographically organized in discrete brain networks, and by much faster (1-80 Hz) electrical oscillations. To investigate the relationship between hemodynamic and electrical oscillations, we have adopted a completely data-driven approach that combines information from simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). Using independent component analysis on the fMRI data, we identified six widely distributed resting state networks. The blood oxygenation level-dependent signal fluctuations associated with each network were correlated with the EEG power variations of delta, theta, alpha, beta, and gamma rhythms. Each functional network was characterized by a specific electrophysiological signature that involved the combination of different brain rhythms. Moreover, the joint EEG/fMRI analysis afforded a finer physiological fractionation of brain networks in the resting human brain. This result supports for the first time in humans the coalescence of several brain rhythms within large-scale brain networks as suggested by biophysical studies.

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Stress- and allostasis-induced brain plasticity.

Bruce McEwen, Peter J. Gianaros (2011)

The brain is the key organ of stress processes. It determines what individuals will experience as stressful, it orchestrates how individuals will cope with stressful experiences, and it changes both functionally and structurally as a result of stressful experiences. Within the brain, a distributed, dynamic, and plastic neural circuitry coordinates, monitors, and calibrates behavioral and physiological stress response systems to meet the demands imposed by particular stressors. These allodynamic processes can be adaptive in the short term (allostasis) and maladaptive in the long term (allostatic load). Critically, these processes involve bidirectional signaling between the brain and body. Consequently, allostasis and allostatic load can jointly affect vulnerability to brain-dependent and stress-related mental and physical health conditions. This review focuses on the role of brain plasticity in adaptation to, and pathophysiology resulting from, stressful experiences. It also considers interventions to prevent and treat chronic and prevalent health conditions via allodynamic brain mechanisms.

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Pathophysiology of migraine.

Daniela Pietrobon, Michael A. Moskowitz (2013)

Migraine is a collection of perplexing neurological conditions in which the brain and its associated tissues have been implicated as major players during an attack. Once considered exclusively a disorder of blood vessels, compelling evidence has led to the realization that migraine represents a highly choreographed interaction between major inputs from both the peripheral and central nervous systems, with the trigeminovascular system and the cerebral cortex among the main players. Advances in in vivo and in vitro technologies have informed us about the significance to migraine of events such as cortical spreading depression and activation of the trigeminovascular system and its constituent neuropeptides, as well as about the importance of neuronal and glial ion channels and transporters that contribute to the putative cortical excitatory/inhibitory imbalance that renders migraineurs susceptible to an attack. This review focuses on emerging concepts that drive the science of migraine in both a mechanistic direction and a therapeutic direction.

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Author and article information

Contributors

Alessandro Tessitore

Antonio Russo

Alfonso Giordano

Francesca Conte

Daniele Corbo

Manuela De Stefano

Sossio Cirillo

Mario Cirillo

Fabrizio Esposito

Gioacchino Tedeschi

Journal

Journal ID (nlm-ta): J Headache Pain

Journal ID (iso-abbrev): J Headache Pain

Title: The Journal of Headache and Pain

Publisher: Springer

ISSN (Print): 1129-2369

ISSN (Electronic): 1129-2377

Publication date (Print): 2013

Publication date (Electronic): 8 November 2013

Volume: 14

Issue: 1

Page: 89

Affiliations

[1 ]Department of Neurology, Second University of Naples, Piazza Miraglia 2 - I-80138, Naples, Italy

[2 ]Institute for Diagnosis and Care “Hermitage Capodimonte”, Naples, Italy

[3 ]Neuroradiology Service, Second University of Naples, Naples, Italy

[4 ]Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands

[5 ]Department of Medicine and Surgery, University of Salerno, Salerno, Italy

Article

Publisher ID: 1129-2377-14-89

DOI: 10.1186/1129-2377-14-89

PMC ID: 3832236

PubMed ID: 24207164

SO-VID: 621661f4-8feb-4baf-bb46-9f47ed7379d6

License:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Disrupted default mode network connectivity in migraine without aura

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Abstract

Background

Methods

Results

Conclusions

Related collections

Irish Journal of Paramedicine

Most cited references 26

Electrophysiological signatures of resting state networks in the human brain.

Stress- and allostasis-induced brain plasticity.

Pathophysiology of migraine.

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