Inhibitory effect of baicalin on orthodontically induced inflammatory
root resorption in rats

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Abstract

Objective

This study investigated the inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats.

Methods

Forty-five male Wistar rats were randomly divided into three groups of 15 rats each. Fifty grams of force was used to establish an orthodontic tooth movement model. Baicalin (40 mg/kg) was locally injected into rats in the baicalin group at 3-day intervals; concurrently, normal saline was injected into rats in the negative control group. On the 21st day after orthodontic treatment, the tooth movement distance and root resorption area ratio were measured. Histomorphology changes were observed by hematoxylin and eosin staining and immunohistochemistry.

Results

There was no significant difference in tooth movement distance between groups. The root resorption area ratio was significantly lower in the baicalin group than in the negative control group. Runx-2 expression was significantly higher in the baicalin group than in the negative control group, while tumor necrosis factor (TNF)-α expression was significantly lower in the baicalin group than in the negative control group.

Conclusions

Baicalin inhibits orthodontically induced inflammatory root resorption by enhancing the expression of Runx-2 and reducing the expression of TNF-α, but does not affect tooth movement distance.

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Most cited references 32

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The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation.

Li-li Cui, Liang Feng, Zhen-hai Zhang … (2014)

Baicalin holds a protective effect on inflammatory responses in several diseases. However, its molecular mechanism of anti-inflammatory activity on ulcerative colitis (UC) remains unknown. The present study was conducted to verify whether the anti-inflammation effect of baicalin on experimental colitis is via inhibiting TLR4/NF-κB pathway activation.

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Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses.

Mukti Nayak, Anurodh Agrawal, Sudeshna Bose … (2014)

Baicalin, a flavonoid, has been shown to have antiviral and anti-inflammatory activities, although the mechanism of action has been unknown. Therefore, attempts were made to analyse the mechanism behind the antiviral effects of baicalin using an influenza A virus (IAV) model in vitro and in vivo.

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Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.

Jieyan V. Chen, L. Xu, Anna W H Cheung … (2011)

Flavonoids, a group of natural compounds found in a variety of vegetables and herbal medicines, have been intensively reported on regarding their estrogen-like activities and particularly their ability to affect bone metabolism. Here, different subclasses of flavonoids were screened for their osteogenic properties by measuring alkaline phosphatase activity in cultured rat osteoblasts. The flavone baicalin derived mainly from the roots of Scutellaria baicalensis showed the strongest induction of alkaline phosphatase activity. In cultured osteoblasts, application of baicalin increased significantly the osteoblastic mineralization and the levels of mRNAs encoding the bone differentiation markers, including osteonectin, osteocalcin, and collagen type 1α1. Interestingly, the osteogenic effect of baicalin was not mediated by its estrogenic activity. In contrast, baicalin promoted osteoblastic differentiation via the activation of the Wnt/β-catenin signaling pathway; the activation resulted in the phosphorylation of glycogen synthase kinase 3β and, subsequently, induced the nuclear accumulation of the β-catenin, leading to the transcription activation of Wnt-targeted genes for osteogenesis. The baicalin-induced osteogenic effects were fully abolished by DKK-1, a blocker of Wnt/β-catenin receptor. Moreover, baicalin also enhanced the mRNA expression of osteoprotegerin, which could regulate indirectly the activation of osteoclasts. Taken together, our results suggested that baicalin could act via Wnt/β-catenin signaling to promote osteoblastic differentiation. The osteogenic flavonoids could be very useful in finding potential drugs, or food supplements, for treating post-menopausal osteoporosis.

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Author and article information

Journal

Journal ID (nlm-ta): J Int Med Res

Journal ID (iso-abbrev): J. Int. Med. Res

Journal ID (publisher-id): IMR

Journal ID (hwp): spimr

Title: The Journal of International Medical Research

Publisher: SAGE Publications (Sage UK: London, England )

ISSN (Print): 0300-0605

ISSN (Electronic): 1473-2300

Publication date (Electronic): 16 September 2020

Publication date Collection: September 2020

Volume: 48

Issue: 9

Electronic Location Identifier: 0300060520955070

Affiliations

[1 ]Department of Orthodontics, Jinan Stomatological Hospital, Jinan, P.R. China

[2 ]Department of Prosthodontics, Binzhou Medical University Hospital, Binzhou, P.R. China

[3-0300060520955070]*Peng Lin and Xin-xing Guo contributed equally to this work and are as co-first author.

Author notes

[*]Tong-bin Liu, Department of Prosthodontics, Binzhou Medical University Hospital, 661 Huanghe Two Road, Binzhou, Shandong 256600, P.R. China. Email: kqyyltb@ 123456163.com

Author information

Peng Lin https://orcid.org/0000-0002-3774-7074

Xin-xing Guo https://orcid.org/0000-0002-0817-0042

Yi-ling Wang https://orcid.org/0000-0001-6399-1161

Zhu-liang Wei https://orcid.org/0000-0002-1368-1285

Hai-yan Xin https://orcid.org/0000-0001-7329-6824

Tong-bin Liu https://orcid.org/0000-0002-9866-7916

Article

Publisher ID: 10.1177_0300060520955070

DOI: 10.1177/0300060520955070

PMC ID: 7509374

PubMed ID: 32938271

SO-VID: 62180bcd-ab43-4400-839c-54c50ad82be9

License:

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

History

Date received : 22 March 2020

Date accepted : 12 August 2020

Funding

Funded by: the Medical and Health Technological Development Program of Shandong Province;

Award ID: No. 2016WS0121

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Keywords: baicalin,orthodontics,root resorption,runx-2,tumor necrosis factor-α,tooth movement,flavonoid,inflammation

Data availability:

Keywords: baicalin, orthodontics, root resorption, runx-2, tumor necrosis factor-α, tooth movement, flavonoid, inflammation

Inhibitory effect of baicalin on orthodontically induced inflammatory root resorption in rats

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Abstract

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Conclusions

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International Journal of Medicine and Medical Research

Most cited references 32

The anti-inflammation effect of baicalin on experimental colitis through inhibiting TLR4/NF-κB pathway activation.

Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses.

Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.

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