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      Using Relativistic Self-Trapping Regime of a High-Intensity Laser Pulse for High-Energy Electron Radiotherapy

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      Plasma Physics Reports
      Pleiades Publishing Ltd

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          Abstract

          Abstract—

          Full-3D particle-in-cell Monte Carlo simulation of a new scheme of electron radiotherapy based on electron acceleration by high-power femtosecond laser pulse propagating in plasma of sub-critical density in the relativistic self-trapping regime (V. Yu. Bychenkov et al., Plasma Phys. Control. Fusion 61, 124004 (2019)) was carried out. Based on the results of simulation of distribution of energy deposited by electron bunches accelerated in such high-efficiency regime, it is demonstrated that a laser facility of \[ \gtrsim {\kern 1pt} 100\] TW class is capable of providing therapy of deep soft-tissue lesions in soft biotissue and this approach has a number of advantages relative to traditional methods of beam therapy.

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          Laser Electron Accelerator

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            Self-Trapping of Optical Beams

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              Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice.

              In vitro studies suggested that sub-millisecond pulses of radiation elicit less genomic instability than continuous, protracted irradiation at the same total dose. To determine the potential of ultrahigh dose-rate irradiation in radiotherapy, we investigated lung fibrogenesis in C57BL/6J mice exposed either to short pulses (≤ 500 ms) of radiation delivered at ultrahigh dose rate (≥ 40 Gy/s, FLASH) or to conventional dose-rate irradiation (≤ 0.03 Gy/s, CONV) in single doses. The growth of human HBCx-12A and HEp-2 tumor xenografts in nude mice and syngeneic TC-1 Luc(+) orthotopic lung tumors in C57BL/6J mice was monitored under similar radiation conditions. CONV (15 Gy) triggered lung fibrosis associated with activation of the TGF-β (transforming growth factor-β) cascade, whereas no complications developed after doses of FLASH below 20 Gy for more than 36 weeks after irradiation. FLASH irradiation also spared normal smooth muscle and epithelial cells from acute radiation-induced apoptosis, which could be reinduced by administration of systemic TNF-α (tumor necrosis factor-α) before irradiation. In contrast, FLASH was as efficient as CONV in the repression of tumor growth. Together, these results suggest that FLASH radiotherapy might allow complete eradication of lung tumors and reduce the occurrence and severity of early and late complications affecting normal tissue.
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                Author and article information

                Journal
                Plasma Physics Reports
                Plasma Phys. Rep.
                Pleiades Publishing Ltd
                1063-780X
                1562-6938
                June 2022
                September 12 2022
                June 2022
                : 48
                : 6
                : 591-598
                Article
                10.1134/S1063780X22600335
                623c77bb-aea8-4beb-81b1-0b843b2bc70d
                © 2022

                https://creativecommons.org/licenses/by/4.0

                https://creativecommons.org/licenses/by/4.0

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