Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reported. In this study, we aimed to reveal clinical significance of Gli1 expression in ESCC and further investigate the potential of Gli1 as a CSC regulator of ESCC by comparing its expression with expressions of other stemness genes in ESCC.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): J. Cancer Res. Clin. Oncol.

Title: Journal of cancer research and clinical oncology

Publisher: Springer Nature

ISSN (Electronic): 1432-1335

ISSN (Print): 0171-5216

Publication date (Electronic): Feb 2017

Volume: 143

Issue: 2

Affiliations

[1 ] Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University, Yanji, 133002, China.

[2 ] Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji, 133002, China.

[3 ] Department of Oncology, Affiliated Hospital of Yanbian University, Yanji, China.

[4 ] Department of Pathology, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, 110-745, Korea. platoshkim@daum.net.

[5 ] Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University, Yanji, 133002, China. xuanyh1@ybu.edu.cn.

[6 ] Institute for Regenerative Medicine, Yanbian University College of Medicine, Yanji, 133002, China. xuanyh1@ybu.edu.cn.

Article

Publisher Item ID: 10.1007/s00432-016-2273-6

DOI: 10.1007/s00432-016-2273-6

PubMed ID: 27680978

SO-VID: 649043f1-9ca0-480d-98ca-c90711261e3e

History

Keywords: Biomarker,CSC,Esophageal squamous cell carcinoma,Gli1

Data availability:

Keywords: Biomarker, CSC, Esophageal squamous cell carcinoma, Gli1

Comments

Comment on this article

scite_

Cited by 22

See all cited by