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      Echocardiographic assessment of pulmonary hypertension: a guideline protocol from the British Society of Echocardiography

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          Abstract

          Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg as confirmed on right heart catheterisation. Traditionally, the pulmonary arterial systolic pressure has been estimated on echo by utilising the simplified Bernoulli equation from the peak tricuspid regurgitant velocity and adding this to an estimate of right atrial pressure. Previous studies have demonstrated a correlation between this estimate of pulmonary arterial systolic pressure and that obtained from invasive measurement across a cohort of patients. However, for an individual patient significant overestimation and underestimation can occur and the levels of agreement between the two is poor. Recent guidance has suggested that echocardiographic assessment of pulmonary hypertension should be limited to determining the probability of pulmonary hypertension being present rather than estimating the pulmonary artery pressure. In those patients in whom the presence of pulmonary hypertension requires confirmation, this should be done with right heart catheterisation when indicated. This guideline protocol from the British Society of Echocardiography aims to outline a practical approach to assessing the probability of pulmonary hypertension using echocardiography and should be used in conjunction with the previously published minimum dataset for a standard transthoracic echocardiogram.

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          Most cited references29

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          Left ventricular heart failure and pulmonary hypertension†

          In patients with left ventricular heart failure (HF), the development of pulmonary hypertension (PH) and right ventricular (RV) dysfunction are frequent and have important impact on disease progression, morbidity, and mortality, and therefore warrant clinical attention. Pulmonary hypertension related to left heart disease (LHD) by far represents the most common form of PH, accounting for 65–80% of cases. The proper distinction between pulmonary arterial hypertension and PH-LHD may be challenging, yet it has direct therapeutic consequences. Despite recent advances in the pathophysiological understanding and clinical assessment, and adjustments in the haemodynamic definitions and classification of PH-LHD, the haemodynamic interrelations in combined post- and pre-capillary PH are complex, definitions and prognostic significance of haemodynamic variables characterizing the degree of pre-capillary PH in LHD remain suboptimal, and there are currently no evidence-based recommendations for the management of PH-LHD. Here, we highlight the prevalence and significance of PH and RV dysfunction in patients with both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), and provide insights into the complex pathophysiology of cardiopulmonary interaction in LHD, which may lead to the evolution from a ‘left ventricular phenotype’ to a ‘right ventricular phenotype’ across the natural history of HF. Furthermore, we propose to better define the individual phenotype of PH by integrating the clinical context, non-invasive assessment, and invasive haemodynamic variables in a structured diagnostic work-up. Finally, we challenge current definitions and diagnostic short falls, and discuss gaps in evidence, therapeutic options and the necessity for future developments in this context.
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            Echocardiography in pulmonary arterial hypertension: from diagnosis to prognosis.

            Pulmonary arterial hypertension is most often diagnosed in its advanced stages because of the nonspecific nature of early symptoms and signs. Although clinical assessment is essential when evaluating patients with suspected pulmonary arterial hypertension, echocardiography is a key screening tool in the diagnostic algorithm. It provides an estimate of pulmonary artery pressure, either at rest or during exercise, and is useful in ruling out secondary causes of pulmonary hypertension. In addition, echocardiography is valuable in assessing prognosis and treatment options, monitoring the efficacy of specific therapeutic interventions, and detecting the preclinical stages of disease. Copyright © 2013 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
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              A simple method for noninvasive estimation of pulmonary vascular resistance.

              We sought to test whether the ratio of peak tricuspid regurgitant velocity (TRV, ms) to the right ventricular outflow tract time-velocity integral (TVI(RVOT), cm) obtained by Doppler echocardiography (TRV/TVI(RVOT)) provides a clinically reliable method to determine pulmonary vascular resistance (PVR). Pulmonary vascular resistance is an important hemodynamic variable used in the management of patients with cardiovascular and pulmonary disease. Right-heart catheterization, with its associated disadvantages, is required to determine PVR. However, a reliable noninvasive method is unavailable. Simultaneous Doppler echocardiographic examination and right-heart catheterization were performed in 44 patients. The ratio of TRV/TVI(RVOT) was then correlated with invasive PVR measurements using regression analysis. An equation was modeled to calculate PVR in Wood units (WU) using echocardiography, and the results were compared with invasive PVR measurements using the Bland-Altman analysis. Using receiver-operating characteristics curve analysis, a cutoff value for the Doppler equation was generated to determine PVR >2WU. As calculated by Doppler echocardiography, TRV/TVI(RVOT) correlated well (r = 0.929, 95% confidence interval 0.87 to 0.96) with invasive PVR measurements. The Bland-Altman analysis between PVR obtained invasively and that by echocardiography, using the equation: PVR = TRV/TVI(RVOT) x 10 + 0.16, showed satisfactory limits of agreement (mean 0 +/- 0.41). A TRV/TVI(RVOT) cutoff value of 0.175 had a sensitivity of 77% and a specificity of 81% to determine PVR >2WU. Doppler echocardiography may provide a reliable, noninvasive method to determine PVR.
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                Author and article information

                Journal
                Echo Res Pract
                Echo Res Pract
                echo
                Echo Research and Practice
                Bioscientifica Ltd (Bristol )
                2055-0464
                September 2018
                11 May 2018
                : 5
                : 3
                : G11-G24
                Affiliations
                [1 ]Royal United Hospital Bath NHS Foundation Trust , Bath, UK
                [2 ]Nottingham University Hospitals NHS Trust , Nottingham, UK
                [3 ]Colchester Hospital NHS Trust , Colchester, UK
                [4 ]West Suffolk Hospital NHS Trust , Bury St Edmonds, UK
                [5 ]Hammersmith Hospital , Imperial College London, London, UK
                [6 ]Royal Free London NHS Foundation Trust – Cardiology , London, UK
                [7 ]West Suffolk NHS Foundation Trust , Bury Saint Edmunds, UK
                [8 ]Liverpool John Moores University , Research Institute for Sports and Exercise Physiology, Liverpool, UK
                [9 ]Papworth Hospital NHS Foundation Trust , Cambridge, UK
                [10 ]Leeds Teaching Hospitals NHS Trust , Leeds, UK
                [11 ]Papworth Hospital , Cambridge, UK
                [12 ]Queen Alexandra Hospital , Portsmouth, UK
                [13 ]Imperial College London , NHLI, National Heart & Lung Institute, London, UK
                [14 ]Imperial College London , National Pulmonary Hypertension Service, London, UK
                [15 ]Hammersmith Hospital , London, UK
                [16 ]St Bartholomew’s Hospital , Barts’ Heart Centre, London, UK
                [17 ]Royal Liverpool and Broadgreen University Hospitals NHS Trust , Liverpool, UK
                [18 ]University Hospital Birmingham and University of Birmingham , Birmingham, UK
                Author notes
                Correspondence should be addressed to D Augustine: daniel.augustine@ 123456nhs.net

                *(D Augustine is the Lead Author)

                (Guideline Chairs: T Mathew and V Sharma)

                The publication of this article was sponsored by Actelion Pharmaceuticals Ltd. The article was produced by the British Society of Echocardiography independently of Actelion Pharmaceuticals Ltd and they were not able to influence its content. Peer review was carried out independently by the journal’s editorial board, based on scientific merit alone.

                Article
                ERP170071
                10.1530/ERP-17-0071
                6055509
                30012832
                6514101e-e638-4f40-bdc7-3384e3536408
                © 2018 The British Society of Echocardiography

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 24 April 2018
                : 11 May 2018
                Categories
                Guidelines and Recommendations

                pulmonary hypertension,echocardiography,guideline
                pulmonary hypertension, echocardiography, guideline

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