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      Inhibin Suppresses in vivo Growth Hormone Secretion

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          Although the effects of inhibin on gonadotropin synthesis and secretion have been extensively studied, the role of inhibin in the neuroregulation of in vivo growth hormone (GH) secretion still remains to be elucidated. In the present work, we investigated the effects of inhibin on spontaneous GH secretion in three different groups of conscious adult male rats: intact, gonadectomized, and dihydrotestosterone (DHT)-treated gonadectomized animals. We found that inhibin administration (100 µg/kg, i.v.) led to a marked suppression in spontaneous GH secretion in all the groups studied. This significant decrease was assessed by the area under the curve in intact (311.1 ± 163.3 vs. 3,882.1 ± 1,084.6 ng/ml/6 h, p < 0.01), gonadectomized (416.6 ± 120.9 vs. 2,078.5 ± 298.4 ng/ml/6 h, p < 0.01) and gondadectomized rats treated with DHT (755.0 ± 102.3 vs. 4,539.3 ± 1,670.6 ng/ml/6 h, p < 0.01). Furthermore, intravenous inhibin significantly reduced in vivo GH responses to GHRH (10 µg/kg, i.v.) in both intact and gonadectomized rats. These findings suggest a role of inhibin on in vivo GH secretion in the male rat.

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          Differential effects of in vivo estrogen administration on hypothalamic growth hormone releasing hormone and somatostatin gene expression

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            Effects of antiandrogens and ethane dimethane sulphonate (EDS) on gene expression, free subunits, bioactivity and secretion of pituitary gonadotrophins in male rats


              Author and article information

              S. Karger AG
              November 1998
              18 November 1998
              : 68
              : 5
              : 293-296
              a Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, and b Department of Fundamental Biology, Faculty of Sciences, University of Vigo, Spain
              54377 Neuroendocrinology 1998;68:293–296
              © 1998 S. Karger AG, Basel

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