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      Inhibin Suppresses in vivo Growth Hormone Secretion

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          Abstract

          Although the effects of inhibin on gonadotropin synthesis and secretion have been extensively studied, the role of inhibin in the neuroregulation of in vivo growth hormone (GH) secretion still remains to be elucidated. In the present work, we investigated the effects of inhibin on spontaneous GH secretion in three different groups of conscious adult male rats: intact, gonadectomized, and dihydrotestosterone (DHT)-treated gonadectomized animals. We found that inhibin administration (100 µg/kg, i.v.) led to a marked suppression in spontaneous GH secretion in all the groups studied. This significant decrease was assessed by the area under the curve in intact (311.1 ± 163.3 vs. 3,882.1 ± 1,084.6 ng/ml/6 h, p < 0.01), gonadectomized (416.6 ± 120.9 vs. 2,078.5 ± 298.4 ng/ml/6 h, p < 0.01) and gondadectomized rats treated with DHT (755.0 ± 102.3 vs. 4,539.3 ± 1,670.6 ng/ml/6 h, p < 0.01). Furthermore, intravenous inhibin significantly reduced in vivo GH responses to GHRH (10 µg/kg, i.v.) in both intact and gonadectomized rats. These findings suggest a role of inhibin on in vivo GH secretion in the male rat.

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          Most cited references 2

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          Differential effects of in vivo estrogen administration on hypothalamic growth hormone releasing hormone and somatostatin gene expression

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            Effects of antiandrogens and ethane dimethane sulphonate (EDS) on gene expression, free subunits, bioactivity and secretion of pituitary gonadotrophins in male rats

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              Author and article information

              Journal
              NEN
              Neuroendocrinology
              10.1159/issn.0028-3835
              Neuroendocrinology
              S. Karger AG
              0028-3835
              1423-0194
              1998
              November 1998
              18 November 1998
              : 68
              : 5
              : 293-296
              Affiliations
              a Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, and b Department of Fundamental Biology, Faculty of Sciences, University of Vigo, Spain
              Article
              54377 Neuroendocrinology 1998;68:293–296
              10.1159/000054377
              9822796
              © 1998 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 2, References: 18, Pages: 4
              Categories
              Rapid Communication

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