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      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Jayne Tierney and colleagues offer guidance on how to spot a well-designed and well-conducted individual participant data meta-analysis.

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          Most cited references83

          • Record: found
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          The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials

          Julian P. T. Higgins, Douglas G. Altman, Peter C. Gøtzsche … (2014)
          Flaws in the design, conduct, analysis, and reporting of randomised trials can cause the effect of an intervention to be underestimated or overestimated. The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate
          Article 0 comments Cited 7147 times – based on 0 reviews     Review now
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            Meta-analysis in clinical trials

            Rebecca DerSimonian, Nan Laird (1986)
            Article 0 comments Cited 3472 times – based on 0 reviews     Review now
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              Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials

              J. A. C. Sterne, A J Sutton, J P A Ioannidis … (2012)
              Article 0 comments Cited 1286 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): PLoS Med
                Journal ID (iso-abbrev): PLoS Med
                Journal ID (publisher-id): plos
                Journal ID (pmc): plosmed
                Title: PLoS Medicine
                Publisher: Public Library of Science (San Francisco, CA USA )
                ISSN (Print): 1549-1277
                ISSN (Electronic): 1549-1676
                Publication date (Electronic): 21 July 2015
                Publication date Collection: July 2015
                Volume: 12
                Issue: 7
                Electronic Location Identifier: e1001855
                Affiliations
                [1 ]MRC Clinical Trials Unit at University College London, London, United Kingdom
                [2 ]Research Institute of Primary Care and Health Sciences, Keele University, Keele, United Kingdom
                [3 ]MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom
                [4 ]Centre for Reviews and Dissemination, University of York, York, United Kingdom
                [5 ]Centre for Public Health, Queens University Belfast, Belfast, United Kingdom
                [6 ]Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
                Author notes

                We have read the journal's policy and have the following potential conflicts. JFT, LS, MC and MR are co-convenors of the Cochrane IPD Methods Group. All authors have been involved in the conduct and publication of IPD meta-analyses, related methodological research and guidance on the IPD approach to systematic review, and receive funding for these activities.

                Contributed to the writing of the manuscript: JFT CV RR CTS LS MC MR. Wrote the first draft of the manuscript: JFT CV RR CTS LS MC MR. Agree with the manuscript’s results and conclusions: JFT CV RR CTS LS MC MR. All authors have read, and confirm that they meet, ICMJE criteria for authorship.

                Article
                Publisher ID: PMEDICINE-D-13-04070
                DOI: 10.1371/journal.pmed.1001855
                PMC ID: 4510878
                PubMed ID: 26196287
                SO-VID: 662a3dab-c28b-4304-bb54-426579b3e2e8
                Copyright statement: Copyright @ 2015
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

                History
                Page count
                Figures: 0, Tables: 2, Pages: 16
                Funding
                This work was supported by a grant (R20)from the UK Medical Research Council Network of Hubs for Trials Methodology Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Subject: Guidelines and Guidance

                ScienceOpen disciplines: Medicine
                Data availability:
                ScienceOpen disciplines: Medicine

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