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      Beyond clustering: mean-field dynamics on networks with arbitrary subgraph composition

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          Abstract

          Clustering is the propensity of nodes that share a common neighbour to be connected. It is ubiquitous in many networks but poses many modelling challenges. Clustering typically manifests itself by a higher than expected frequency of triangles, and this has led to the principle of constructing networks from such building blocks. This approach has been generalised to networks being constructed from a set of more exotic subgraphs. As long as these are fully connected, it is then possible to derive mean-field models that approximate epidemic dynamics well. However, there are virtually no results for non-fully connected subgraphs. In this paper, we provide a general and automated approach to deriving a set of ordinary differential equations, or mean-field model, that describes, to a high degree of accuracy, the expected values of system-level quantities, such as the prevalence of infection. Our approach offers a previously unattainable degree of control over the arrangement of subgraphs and network characteristics such as classical node degree, variance and clustering. The combination of these features makes it possible to generate families of networks with different subgraph compositions while keeping classical network metrics constant. Using our approach, we show that higher-order structure realised either through the introduction of loops of different sizes or by generating networks based on different subgraphs but with identical degree distribution and clustering, leads to non-negligible differences in epidemic dynamics.

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          The online version of this article (doi:10.1007/s00285-015-0884-1) contains supplementary material, which is available to authorized users.

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          Emergence of scaling in random networks

          Systems as diverse as genetic networks or the world wide web are best described as networks with complex topology. A common property of many large networks is that the vertex connectivities follow a scale-free power-law distribution. This feature is found to be a consequence of the two generic mechanisms that networks expand continuously by the addition of new vertices, and new vertices attach preferentially to already well connected sites. A model based on these two ingredients reproduces the observed stationary scale-free distributions, indicating that the development of large networks is governed by robust self-organizing phenomena that go beyond the particulars of the individual systems.
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            Epidemic spreading in scale-free networks

            The Internet, as well as many other networks, has a very complex connectivity recently modeled by the class of scale-free networks. This feature, which appears to be very efficient for a communications network, favors at the same time the spreading of computer viruses. We analyze real data from computer virus infections and find the average lifetime and prevalence of viral strains on the Internet. We define a dynamical model for the spreading of infections on scale-free networks, finding the absence of an epidemic threshold and its associated critical behavior. This new epidemiological framework rationalize data of computer viruses and could help in the understanding of other spreading phenomena on communication and social networks.
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              A critical point for random graphs with a given degree sequence

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                Author and article information

                Contributors
                MR284@sussex.ac.uk
                L.Berthouze@sussex.ac.uk
                i.z.kiss@sussex.ac.uk
                Journal
                J Math Biol
                J Math Biol
                Journal of Mathematical Biology
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0303-6812
                1432-1416
                17 April 2015
                17 April 2015
                2016
                : 72
                : 255-281
                Affiliations
                [ ]Department of Mathematics, School of Mathematical and Physical Sciences, University of Sussex, Falmer, Brighton, BN1 9QH UK
                [ ]Centre for Computational Neuroscience and Robotics, University of Sussex, Falmer, Brighton, BN1 9QH UK
                Article
                884
                10.1007/s00285-015-0884-1
                4698307
                25893260
                1405.6234
                6721d9d4-ae93-4afa-97bd-6ac1442d59f0
                © The Author(s) 2015

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 8 July 2014
                : 26 March 2015
                Categories
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                Custom metadata
                © Springer-Verlag Berlin Heidelberg 2016

                Quantitative & Systems biology
                network,subgraph,motif,high-order structure ,epidemic,05c82,37n25,60j28
                Quantitative & Systems biology
                network, subgraph, motif, high-order structure , epidemic, 05c82, 37n25, 60j28

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