Judith Grau-Expósito: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SoftwareRole: ValidationRole: Writing – original draftRole: Writing
– review & editing
Laura Luque-Ballesteros: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Jordi Navarro:
ORCID: http://orcid.org/0000-0002-7187-0367
Role: ResourcesRole: Writing – review & editing
Adrian Curran: Role: ResourcesRole: Writing – review & editing
Joaquin Burgos: Role: ResourcesRole: Writing – review & editing
Esteban Ribera: Role: Resources
Ariadna Torrella: Role: Project administrationRole: ResourcesRole: Writing – review & editing
Bibiana Planas: Role: Project administrationRole: ResourcesRole: Writing – review & editing
Rosa Badía:
ORCID: http://orcid.org/0000-0002-8222-5697
Role: ResourcesRole: Writing – review & editing
Mario Martin-Castillo:
ORCID: http://orcid.org/0000-0001-6435-0374
Role: Project administrationRole: Writing – review & editing
Jesús Fernández-Sojo:
ORCID: http://orcid.org/0000-0002-4016-0020
Role: ResourcesRole: Writing – review & editing
Meritxell Genescà: Role: InvestigationRole: Writing – review & editing
Vicenç Falcó:
ORCID: http://orcid.org/0000-0001-9626-0023
Role: ResourcesRole: Writing – review & editing
Maria J. Buzon:
ORCID: http://orcid.org/0000-0003-4427-9413
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: Writing
– original draftRole: Writing – review & editing
Ronald Swanstrom: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
19
August
2019
Publication date Collection:
August
2019
Volume: 15
Issue: 8
Electronic Location Identifier: e1007991
Affiliations
[1
]
Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Institut de Recerca
(VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
[2
]
Banc de Sang i Teixits, Hospital Universitari Vall d'Hebron, Universitat Autònoma
de Barcelona, Spain
University of North Carolina at Chapel Hill, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PPATHOGENS-D-19-00494
DOI: 10.1371/journal.ppat.1007991
PMC ID: 6715238
PubMed ID: 31425551
SO-VID: 677d164e-d491-4866-b9ce-70114f5f6879
Copyright © © 2019 Grau-Expósito et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000060, National Institute of Allergy and Infectious Diseases;
Award ID: R21AI118411
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4427-9413
Maria J. Buzon
Funded by: funder-id http://dx.doi.org/10.13039/501100010198, Ministerio de Economía, Industria y Competitividad, Gobierno de España;
Award ID: SAF2015-67334-R
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4427-9413
Maria J. Buzon
Funded by: funder-id http://dx.doi.org/10.13039/100008021, Bristol-Myers Squibb Canada;
Award ID: PfC-2015 AI424-564
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4427-9413
Maria J. Buzon
Funded by: funder-id http://dx.doi.org/10.13039/501100004587, Instituto de Salud Carlos III;
Award ID: CP17/00179, Miguel Servet Program
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4427-9413
Maria J. Buzon
Funded by: funder-id http://dx.doi.org/10.13039/100005564, Gilead Sciences;
Award ID: GLD17-00204
Award Recipient
:
ORCID: http://orcid.org/0000-0003-4427-9413
Maria J. Buzon
Funded by: funder-id http://dx.doi.org/10.13039/501100004587, Instituto de Salud Carlos III;
Award ID: PI17/01470
Award Recipient
:
Meritxell Genescà
Funded by: funder-id http://dx.doi.org/10.13039/501100010198, Ministerio de Economía, Industria y Competitividad, Gobierno de España;
Award ID: RD16/0025/0007
Award Recipient
:
Esteban Ribera
Funded by: funder-id http://dx.doi.org/10.13039/501100003030, Agència de Gestió d’Ajuts Universitaris i de Recerca;
Award ID: PERIS
Award Recipient
:
Meritxell Genescà
This study was supported by the American National Institutes of Health (grant R21AI118411
to MJB), the Spanish Secretariat of Science and Innovation and FEDER funds (grant
SAF2015-67334-R [MINECO/FEDER]), a unrestricted research grant from Bristol-Myers
Squibb S.A.U (PfC-2015 AI424-564) to MJB, the Spanish “Ministerio de Economía y Competitividad,
Instituto de Salud Carlos III” (ISCIII, PI17/01470) to M.G, a research grant from
Gilead Sciences (GLD17-00204) to M.B, GeSIDA and the Spanish AIDS network “Red Temática
Cooperativa de Investigación en SIDA” (RD16/0025/0007) to ER. The Miguel Servet program
funded by the Spanish Health Institute Carlos III (CP17/00179) to MJB. The “Pla estratègic
de recerca i innovació en salut” (PERIS), from the Catalan Government to MG. The funders
had no role in study design, data collection and analysis, the decision to publish
or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Replication
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Cells
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Apoptosis
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Persistence and Latency
Subject:
Biology and Life Sciences
Subject:
Toxicology
Subject:
Toxicity
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Toxicology
Subject:
Toxicity
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Blood cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells
Subject:
Biology and life sciences
Subject:
Cell biology
Subject:
Cellular types
Subject:
Animal cells
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells
Subject:
Biology and life sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells
Subject:
Medicine and health sciences
Subject:
Immunology
Subject:
Immune cells
Subject:
White blood cells
Subject:
T cells
Subject:
Memory T cells