Simvastatin Inhibits Tumor Growth and Migration by Mediating Caspase-1-Dependent Pyroptosis in Glioblastoma Multiforme.

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Abstract

Glioblastoma multiforme (GBM) is the most common and lethal central nervous system cancer and is associated with a poor prognosis. Simvastatin, a kind of widely used hypolipidemic agent, has been investigated for its beneficial effects on various types of cancers. The main purpose of this paper is to investigate the potential inhibitory effects of simvastatin on GBM and the underlying mechanism.

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Author and article information

Journal

Journal ID (iso-abbrev): World Neurosurg

Title: World neurosurgery

Publisher: Elsevier BV

ISSN (Electronic): 1878-8769

ISSN (Print): 1878-8750

Publication date (Electronic): Sep 2022

Volume: 165

Affiliations

[1 ] Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

[2 ] Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

[3 ] Department of Histology and Embryology, Basic Medical Science College, Harbin Medical University, Harbin, Heilongjiang Province, China.

[4 ] Department of Central Operating Room, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

[5 ] Department of Abdominal Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

[6 ] Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. Electronic address: xiechunchengHMU@hotmail.com.

Article

Publisher Item ID: S1878-8750(22)00382-5

DOI: 10.1016/j.wneu.2022.03.089

PubMed ID: 35342027

SO-VID: 6803c452-2037-403f-ac4b-8513e89d4a45

History

Keywords: miR-214,Caspase-1,Glioblastoma multiforme,Pyroptosis,Simvastatin

Data availability:

Keywords: miR-214, Caspase-1, Glioblastoma multiforme, Pyroptosis, Simvastatin

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