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      • Record: found
      • Abstract: found
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      The Intermediate Filament Cytoskeleton of the Lens: An Ever Changing Network through Development and Differentiation

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          Abstract

          In the eye lens, intermediate filament proteins form two morphologically distinct polymers, 10-nm intermediate-sized filaments and beaded filaments. Coincidently, the beaded filament polymer and the proteins filensin and CP49 are specific to lens fibre cells and are therefore excellent markers for fibre cell differentiation. In the adult lens, filensin and CP49 are maintained throughout all stages of lens fibre cell differentiation whilst vimentin is apparently lost at a specific stage from the deeper cortical fibres. The expression of CP49 and filensin is coincident with the presence of beaded filaments suggesting these proteins are filament components. In association with α-crystallin, CP49 and filensin form beaded filaments in vitro. During fibre cell differentiation, filensin and CP49 are post-transla-tionally modified. In the case of filensin, proteolysis results in two functionally distinct fragment sets, one derived from the α-helical rod domain and the other from the C-terminal tail domain of filensin. It is proposed that both filensin and CP49 are critically involved in organising the cyto-plasmic and plasma membrane domains of the fibre cell and therefore essential to the optical properties of the lens.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          978-3-8055-6304-8
          978-3-318-00086-3
          0030-3747
          1423-0259
          1996
          1996
          11 December 2009
          : 28
          : Suppl 1
          : 58-61
          Affiliations
          Department of Biochemistry, Medical Sciences Institute, University of Dundee, Scotland
          Article
          267946 Ophthalmic Res 1996;28:58–61
          10.1159/000267946
          8727967
          686e5070-7eae-4cee-8cc9-a78dbf3d1370
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 4
          Categories
          Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          CP49,Beaded filaments,Review,α-Crystallin,Filensin,Vimentin

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