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      Ultrasound-assisted extraction and characteristics of maize polysaccharides from different sites

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          Abstract

          Antitumor, antioxidant, hypoglycemic, and immunomodulatory properties are all exhibited by maize polysaccharides. With the increasing sophistication of maize polysaccharide extraction methods, enzymatic method is no longer limited to a single enzyme to extract polysaccharides, and is more often used in combination with ultrasound or microwave, or combination with different enzymes. Ultrasound has a good cell wall-breaking effect, making it easier to dislodge lignin and hemicellulose from the cellulose surface of the maize husk. The “water extraction and alcohol precipitation” method is the simplest but most resource- and time-consuming process. However, the “ultrasound-assisted extraction” and “microwave-assisted extraction” methods not only compensate for the shortcoming, but also increase the extraction rate. Herein, the preparation, structural analysis, and activities of maize polysaccharides were analyzed and discussed.

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          Diabetes mellitus and oxidative stress—A concise review

          Human body is continuously exposed to different types of agents that results in the production of reactive species called as free radicals (ROS/RNS) which by the transfer of their free unpaired electron causes the oxidation of cellular machinery. In order to encounter the deleterious effects of such species, body has got endogenous antioxidant systems or it obtains exogenous antioxidants from diet that neutralizes such species and keeps the homeostasis of body. Any imbalance between the RS and antioxidants leads to produce a condition known as “oxidative stress” that results in the development of pathological condition among which one is diabetes. Most of the studies reveal the inference of oxidative stress in diabetes pathogenesis by the alteration in enzymatic systems, lipid peroxidation, impaired Glutathione metabolism and decreased Vitamin C levels. Lipids, proteins, DNA damage, Glutathione, catalane and superoxide dismutase are various biomarkers of oxidative stress in diabetes mellitus. Oxidative stress induced complications of diabetes may include stroke, neuropathy, retinopathy and nephropathy. The basic aim of this review was to summarize the basics of oxidative stress in diabetes mellitus.
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            Advances in ultrasound assisted extraction of bioactive compounds from cash crops – A review

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              The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy

              Macrophages have a leading position in the tumor microenvironment (TME) which paves the way to carcinogenesis. Initially, monocytes and macrophages are recruited to the sites where the tumor develops. Under the guidance of different microenvironmental signals, macrophages would polarize into two functional phenotypes, named as classically activated macrophages (M1) and alternatively activated macrophages (M2). Contrary to the anti-tumor effect of M1, M2 exerts anti-inflammatory and tumorigenic characters. In progressive tumor, M2 tumor-associated macrophages (TAMs) are in the majority, being vital regulators reacting upon TME. This review elaborates on the role of TAMs in tumor progression. Furthermore, prospective macrophage-focused therapeutic strategies, including drugs not only in clinical trials but also at primary research stages, are summarized followed by a discussion about their clinical application values. Nanoparticulate systems with efficient drug delivery and improved antitumor effect are also summed up in this article.
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                Author and article information

                Contributors
                Journal
                Ultrason Sonochem
                Ultrason Sonochem
                Ultrasonics Sonochemistry
                Elsevier
                1350-4177
                1873-2828
                20 April 2023
                May 2023
                20 April 2023
                : 95
                : 106416
                Affiliations
                Key Laboratory of Carbohydrate Science and Engineering, Chongqing Normal University, Chongqing 401331, China
                Author notes
                [* ]Corresponding author. huangdoctor226@ 123456163.com
                Article
                S1350-4177(23)00128-1 106416
                10.1016/j.ultsonch.2023.106416
                10160789
                37094477
                68e2b892-085a-4aae-a7fa-2f1f0fa400c1
                © 2023 The Authors. Published by Elsevier B.V.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 12 March 2023
                : 8 April 2023
                : 18 April 2023
                Categories
                Original Research Article

                maize polysaccharides from different parts,ultrasound-assisted extraction,characteristics

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