Validation of a stability-indicating HPLC-UV method for the quantification of acetazolamide in Oral-Mix and Oral-Mix SF

Abstract

This manuscript details the modifications made to the HPLC assay method described in the USP monograph for Acetazolamide Compounded Oral Suspension.

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  The method was modified to allow the quantification of acetazolamide in two new suspension vehicles: Oral Mix and Oral Mix SF;

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  It was validated for linearity, accuracy, precision and specificity;

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  It was demonstrated stability-indicating and suitable for use in a stability study using these vehicles.

Graphical abstract