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      2-hydroxyestrone: the 'good' estrogen.

      The Journal of Endocrinology

      Hydroxylation, Anticarcinogenic Agents, metabolism, Breast Neoplasms, prevention & control, Estrogens, Catechol, Female, Humans, Hydroxyestrones

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          Abstract

          The issue of the role of 2-hydroxyestrone (2-OHE1) in breast cancer has been the subject of considerable controversy as to whether it is carcinogenic or anticarcinogenic. The expanding data base outlined below is most consistent with the conclusion that 2-OHE1 is anticarcinogenic. In every experimental model in which 2-hydroxylation was increased, protection against tumors was achieved. Correspondingly, when 2-hydroxylation was decreased, an increase in cancer risk was observed. Even more dramatically, in the case of laryngeal papillomas induction of 2-hydroxylation with indole-3-carbinol (I3C) has resulted in inhibition of tumor growth during the time that the patients continue to take 13C or vegetables rich in this compound.

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