ScienceOpen:
research and publishing network
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
My ScienceOpen
Sign in
Register
Dashboard
Blog
About
Search
Advanced search
My ScienceOpen
Sign in
Register
Dashboard
Search
Search
Advanced search
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
Blog
About
63
views
0
references
Top references
cited by
468
Cite as...
0 reviews
Review
0
comments
Comment
0
recommends
+1
Recommend
0
collections
Add to
0
shares
Share
Twitter
Sina Weibo
Facebook
Email
2,200
similar
All similar
Record
: found
Abstract
: not found
Article
: not found
Pancreatic cancer
Author(s):
Audrey Vincent
,
Joseph Herman
,
Rich Schulick
,
Ralph H Hruban
,
Michael Goggins
Publication date
Created:
August 2011
Publication date
(Print):
August 2011
Journal:
The Lancet
Publisher:
Elsevier BV
Read this article at
ScienceOpen
Publisher
PMC
Further versions
oa repository (via OAI-PMH doi match)
oa repository (via pmcid lookup)
Powered by
Review
Review article
Invite someone to review
Bookmark
Cite as...
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Substantial progress has been made in our understanding of the biology of pancreatic cancer, and advances in patients' management have also taken place. Evidence is beginning to show that screening first-degree relatives of individuals with several family members affected by pancreatic cancer can identify non-invasive precursors of this malignant disease. The incidence of and number of deaths caused by pancreatic tumours have been gradually rising, even as incidence and mortality of other common cancers have been declining. Despite developments in detection and management of pancreatic cancer, only about 4% of patients will live 5 years after diagnosis. Survival is better for those with malignant disease localised to the pancreas, because surgical resection at present offers the only chance of cure. Unfortunately, 80-85% of patients present with advanced unresectable disease. Furthermore, pancreatic cancer responds poorly to most chemotherapeutic agents. Hence, we need to understand the biological mechanisms that contribute to development and progression of pancreatic tumours. In this Seminar we will discuss the most common and deadly form of pancreatic cancer, pancreatic ductal adenocarcinoma. Copyright © 2011 Elsevier Ltd. All rights reserved.
Related collections
Cancer Metabolism
Author and article information
Journal
Title:
The Lancet
Abbreviated Title:
The Lancet
Publisher:
Elsevier BV
ISSN (Print):
01406736
Publication date Created:
August 2011
Publication date (Print):
August 2011
Volume
: 378
Issue
: 9791
Pages
: 607-620
Article
DOI:
10.1016/S0140-6736(10)62307-0
PMC ID:
3062508
PubMed ID:
21620466
SO-VID:
69b4760b-09bf-4fc5-9b93-014c6e6f8cb3
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
History
Data availability:
Comments
Comment on this article
Sign in to comment
scite_
Similar content
2,200
Procyanidins modulate microRNA expression in pancreatic islets.
Authors:
Anna Castell-Auví
,
Lídia Cedó
,
Jamileh Movassat
…
Curcumin Modulates Pancreatic Adenocarcinoma Cell-Derived Exosomal Function
Authors:
Carlos J. Diaz Osterman
,
James Lynch
,
Patrick Leaf
…
Risk of acute atherosclerotic cardiovascular disease in patients with acute and chronic pancreatitis
Authors:
Li-Chin Sung
,
Chuen-Chau Chang
,
Chao-Shun Lin
…
See all similar
Cited by
920
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors
Authors:
Prashanth Rawla
,
Tagore Sunkara
,
Vinaya Gaduputi
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes
Authors:
Andrew McGuigan
,
Paul G. Kelly
,
Richard C Turkington
…
Epidemiology of pancreatic cancer
Authors:
Milena Ilic
,
Irena Ilic
See all cited by
Version 1
- Current
Version 1
Version 1