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      Naloxone Inhibition of Postprandial Growth Hormone Releasing Hormone-Induced Growth Hormone Release in Obesity

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          The effects of opiate receptor antagonist naloxone on growth hormone (GH) release after growth hormone-releasing hormone (GHRH) administration were investigated, before or after feeding, at 13.00 h, in 20 obese women and in 10 normal women. When GHRH was administered to obese women before a meal at lunch time, the mean peak plasma GH levels were very low, while plasma GH responses significantly increased after feeding. Naloxone, infused at a rate of 1.6 mg/h starting 1 h before GHRH administration (50 µg i.v. as a bolus), was capable of inhibiting GH release induced by administration of GHRH after feeding. On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release. In normal women, naloxone did not significantly modify the GH response to GHRH, both before and after lunch. The inhibitory effect of naloxone indicates that in obese women there is an increased opioid activity, which could represent an abnormal response of the gastrointestinal tract to food ingestion.

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          Author and article information

          S. Karger AG
          02 April 2008
          : 50
          : 5
          : 529-532
          Institutes of aEndocrinology and bInternal Medicine, Catholic University School of Medicine, Rome, Italy
          125276 Neuroendocrinology 1989;50:529–532
          © 1989 S. Karger AG, Basel

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          Pages: 4
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