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      ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIES

      American Journal of Epidemiology

      Oxford University Press (OUP)

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          Abstract

          The concepts that case-referent studies provide for the estimation of "relative risk" only if the illness is "rare", and that the rates and risks themselves are inestimable, are overly superficial and restrictve. The ratio of incidence densities (forces of morbidity)-and thereby the instantaneous risk-ratio-is estimable without any rarity-assumption. Long-term risk-ratio can be computed through the coupling of case-referent data on exposure rates for various age-categories with estimates, possibly from the study itself, or the corresponding age-specific incidence-densities for the exposed and nonexposed combined-but again, no rarity-assumption is involved. Such data also provide for the assessment of exposure-specific absolute incidence-rates and risks. Point estimation of the various parameters can be based on simple relationships among them, and in interval estimation it is sufficient simply to couple the point estimate with the value of the chi square statistic used in significance testing.

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          Author and article information

          Journal
          American Journal of Epidemiology
          Oxford University Press (OUP)
          1476-6256
          0002-9262
          February 1976
          February 01 1976
          February 1976
          February 1976
          February 01 1976
          February 1976
          : 103
          : 2
          : 226-235
          Article
          10.1093/oxfordjournals.aje.a112220
          1251836
          6a5f4e8f-78d7-4a47-ab97-6a08e6db279f
          © 1976

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