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      Left Ventricular Hypertrophy and Diastolic Dysfunction in Healthy Pregnant Women


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          Objective: The purpose of this study was to examine which hemodynamic parameters change under the natural volume overload of pregnancy. Study Design: 46 healthy pregnant women were echocardiographically examined during the course of pregnancy. To evaluate left ventricular diastolic function, mitral inflow and pulmonary venous flow profiles were used. Fractional shortening and left ventricular muscle mass were calculated. Results: In the course of pregnancy the left ventricular muscle mass index increased (from 66 ± 6 to 96 ± 9 g/m<sup>2</sup>), fractional shortening decreased (from 38 ± 4 to 32 ± 6%) and a disturbed diastolic relaxation pattern was documented. Eight weeks after delivery, all left ventricular systolic and diastolic functional parameters returned to normal values. Conclusion: The natural volume overload in pregnancy leads to a reversible ‘physiological’ left ventricular hypertrophy, a short-term decrease in systolic function and a significant change in left ventricular diastolic function.

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          Kann eine linksventrikuläre pathologische Hypertrophie bei arterieller Hypertonie von einer physiologischen Hypertrophie durch Sport unterschieden werden?


            Author and article information

            S. Karger AG
            April 2002
            25 April 2002
            : 97
            : 2
            : 73-78
            aClinic of Cardiology, Pneumology and Angiology, and bClinic of Gynecology and Obstetrics, Heinrich Heine University Düsseldorf, Germany
            57675 Cardiology 2002;97:73–78
            © 2002 S. Karger AG, Basel

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            Page count
            Figures: 2, Tables: 3, References: 25, Pages: 6
            General Cardiology

            General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
            Hemodynamic parameters,Diastolic dysfunction,Left ventricular hypertrophy,Pregnancy,Left ventricular systolic function,Natural volume overload


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