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Biological and clinical aspects of interleukin 6
January 1990
January 1990
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Abstract
Interleukin 6 (IL-6) is a multi-functional cytokine that is produced by a range of
cells and plays a central role in host defense mechanisms. Abnormal production of
IL-6 has been suggested to be involved in glomerulonephritis, plasmacytomagenesis
and in the pathogenesis of autoimmune diseases. In this review, Toshio Hirano and
colleagues discuss the possible involvement of IL-6 in a variety of diseases, the
regulatory mechanism(s) of expression of the IL-6 gene and the structure and function
of the IL-6 receptor.