Bovine coronavirus

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Summary

This review aims to summarize current data describing the characteristics of bovine coronavirus (BCV) and the three clinical syndromes with which this virus is associated. The first half of this paper consists of a general description of the virus, commencing with a brief outline of the methods used for in vitro growth. The structure of the virus is then described in more detail, with particular reference to the structure and functions of the four major viral proteins. This is followed by an outline of the unique replication strategy adopted by coronaviruses. The second half of this review discusses the clinical significance of the virus, beginning with a detailed account of BCV-induced neonatal calf diarrhoea, the clinical syndrome with which this virus is most commonly associated. The clinical and epidemiological importance of BCV respiratory tract infection is then discussed, and finally the evidence supporting the aetiological role of BCV in outbreaks of winter dysentery in adult cattle is examined.

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Most cited references 135

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Sequence of mouse hepatitis virus A59 mRNA 2: Indications for RNA recombination between coronaviruses and influenza C virus

Willem Luytjes, Peter J Bredenbeek, Ans Noten … (1988)

The nucleotide sequence of the unique region of coronavirus MHV-A59 mRNA 2 has been determined. Two open reading frames (ORF) are predicted: ORF1 potentially encodes a protein of 261 amino acids; its amino acid sequence contains elements which indicate nucleotide binding properties. ORF2 predicts a 413 amino acids protein; it lacks a translation initiation codon and is therefore probably a pseudogene. The amino acid sequence of ORF2 shares 30% homology with the HA1 hemagglutinin sequence of influenza C virus. A short stretch of nucleotides immediately upstream of ORF2 shares 83% homology with the MHC class I nucleotide sequences. We discuss the possibilitythat both similarities are the result of recombinations and present a model for the acquisition and the subsequent inactivation of ORF2; the model applies also to MHV-A59-related coronaviruses in which we expect ORF2 to be still functional.

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Author and article information

Journal

Journal ID (nlm-ta): Br Vet J

Journal ID (iso-abbrev): Br. Vet. J

Title: The British Veterinary Journal

Publisher: Published by Elsevier Ltd

ISSN (Print): 0007-1935

ISSN (Electronic): 0007-1935

Publication date PMC-release: 19 November 2007

Publication date (Print): 1993

Publication date (Electronic): 19 November 2007

Volume: 149

Issue: 1

Pages: 51-70

Affiliations

[1]Department of Physiological Sciences, Medical School, University of Newcastle upon Tyne NE2 4HH, UK ^*

Author notes

[*]

Former address: Microbiology Department. Moredun Research Institute, 408 Gilmerton Road, Edinburgh EH 17 7JH.

Article

Publisher ID: S0007-1935(05)80210-6

DOI: 10.1016/S0007-1935(05)80210-6

PMC ID: 7130254

PubMed ID: 8382546

SO-VID: 6c0f9c5e-66ce-444d-b75e-caae34bf95ab

License:

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