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      Growth Hormone Synthesis Decreased after Anterolateral Deafferentation of the Medial Basal Hypothalamus in the Rat

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          Abstract

          To study the role of the hypothalamus in the regulation of growth hormone (GH) synthesis, the rate of amino acid incorporation into GH in vitro was examined in rats with anterolateral deafferentation of the medial basal hypothalamus. Amino acid incorporation into GH (GH synthesis) decreased significantly 7 days after the deafferentation, although prolactin synthesis did not show any significant fluctuations. The serum GH was increased, while the pituitary GH content was decreased. Somatostatin in the stalk median eminence of such deafferentated animals decreased markedly, while GH-releasing hormone was decreased slightly but not significantly. Immunohistochemical examinations revealed that the number of somatostatin nerve terminals in the median eminence decreased markedly, while GH-releasing hormone nerve terminals in the same area remained intact. These findings suggest that neural factor(s) outside the medial basal hypothalamus plays an important role in the regulation of GH synthesis.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1988
          1988
          02 April 2008
          : 47
          : 5
          : 431-436
          Affiliations
          aDepartment of Endocrinology and Internal Medicine, Dokkyo University School of Medicine, Mibu; bDepartment of Physiology, Institute of Endocrinology, Gunma University, Maebashi, Japan
          Article
          124946 Neuroendocrinology 1988;47:431–436
          10.1159/000124946
          3399030
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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