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      Identification of kidney stones in KUB X-ray images using VGG16 empowered with explainable artificial intelligence

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          Abstract

          A kidney stone is a solid formation that can lead to kidney failure, severe pain, and reduced quality of life from urinary system blockages. While medical experts can interpret kidney-ureter-bladder (KUB) X-ray images, specific images pose challenges for human detection, requiring significant analysis time. Consequently, developing a detection system becomes crucial for accurately classifying KUB X-ray images. This article applies a transfer learning (TL) model with a pre-trained VGG16 empowered with explainable artificial intelligence (XAI) to establish a system that takes KUB X-ray images and accurately categorizes them as kidney stones or normal cases. The findings demonstrate that the model achieves a testing accuracy of 97.41% in identifying kidney stones or normal KUB X-rays in the dataset used. VGG16 model delivers highly accurate predictions but lacks fairness and explainability in their decision-making process. This study incorporates the Layer-Wise Relevance Propagation (LRP) technique, an explainable artificial intelligence (XAI) technique, to enhance the transparency and effectiveness of the model to address this concern. The XAI technique, specifically LRP, increases the model's fairness and transparency, facilitating human comprehension of the predictions. Consequently, XAI can play an important role in assisting doctors with the accurate identification of kidney stones, thereby facilitating the execution of effective treatment strategies.

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          Automated detection of COVID-19 cases using deep neural networks with X-ray images

          The novel coronavirus 2019 (COVID-2019), which first appeared in Wuhan city of China in December 2019, spread rapidly around the world and became a pandemic. It has caused a devastating effect on both daily lives, public health, and the global economy. It is critical to detect the positive cases as early as possible so as to prevent the further spread of this epidemic and to quickly treat affected patients. The need for auxiliary diagnostic tools has increased as there are no accurate automated toolkits available. Recent findings obtained using radiology imaging techniques suggest that such images contain salient information about the COVID-19 virus. Application of advanced artificial intelligence (AI) techniques coupled with radiological imaging can be helpful for the accurate detection of this disease, and can also be assistive to overcome the problem of a lack of specialized physicians in remote villages. In this study, a new model for automatic COVID-19 detection using raw chest X-ray images is presented. The proposed model is developed to provide accurate diagnostics for binary classification (COVID vs. No-Findings) and multi-class classification (COVID vs. No-Findings vs. Pneumonia). Our model produced a classification accuracy of 98.08% for binary classes and 87.02% for multi-class cases. The DarkNet model was used in our study as a classifier for the you only look once (YOLO) real time object detection system. We implemented 17 convolutional layers and introduced different filtering on each layer. Our model (available at (https://github.com/muhammedtalo/COVID-19)) can be employed to assist radiologists in validating their initial screening, and can also be employed via cloud to immediately screen patients.
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            Artificial intelligence in healthcare: past, present and future

            Artificial intelligence (AI) aims to mimic human cognitive functions. It is bringing a paradigm shift to healthcare, powered by increasing availability of healthcare data and rapid progress of analytics techniques. We survey the current status of AI applications in healthcare and discuss its future. AI can be applied to various types of healthcare data (structured and unstructured). Popular AI techniques include machine learning methods for structured data, such as the classical support vector machine and neural network, and the modern deep learning, as well as natural language processing for unstructured data. Major disease areas that use AI tools include cancer, neurology and cardiology. We then review in more details the AI applications in stroke, in the three major areas of early detection and diagnosis, treatment, as well as outcome prediction and prognosis evaluation. We conclude with discussion about pioneer AI systems, such as IBM Watson, and hurdles for real-life deployment of AI.
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              On Pixel-Wise Explanations for Non-Linear Classifier Decisions by Layer-Wise Relevance Propagation

              Understanding and interpreting classification decisions of automated image classification systems is of high value in many applications, as it allows to verify the reasoning of the system and provides additional information to the human expert. Although machine learning methods are solving very successfully a plethora of tasks, they have in most cases the disadvantage of acting as a black box, not providing any information about what made them arrive at a particular decision. This work proposes a general solution to the problem of understanding classification decisions by pixel-wise decomposition of nonlinear classifiers. We introduce a methodology that allows to visualize the contributions of single pixels to predictions for kernel-based classifiers over Bag of Words features and for multilayered neural networks. These pixel contributions can be visualized as heatmaps and are provided to a human expert who can intuitively not only verify the validity of the classification decision, but also focus further analysis on regions of potential interest. We evaluate our method for classifiers trained on PASCAL VOC 2009 images, synthetic image data containing geometric shapes, the MNIST handwritten digits data set and for the pre-trained ImageNet model available as part of the Caffe open source package.
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                Author and article information

                Contributors
                adnan@gachon.ac.kr
                ara4013@qatar-med.cornell.edu
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                14 March 2024
                14 March 2024
                2024
                : 14
                : 6173
                Affiliations
                [1 ]School of Computer Science, National College of Business Administration and Economics, ( https://ror.org/02my4wj17) Lahore, 54000 Pakistan
                [2 ]Department of Computer Sciences, Bahria University, ( https://ror.org/02v8d7770) Lahore Campus, Lahore, 54000 Pakistan
                [3 ]Department of Computer Science, Comsats University Islamabad, ( https://ror.org/00nqqvk19) Lahore Campus, Lahore, 54000 Pakistan
                [4 ]Department of Computer Sciences, COMSATS University Islamabad, ( https://ror.org/00nqqvk19) Sahiwal Campus, Sahiwal, 57000 Pakistan
                [5 ]Department of Computer Science, College of Computer Engineering and Sciences, Prince Sattam Bin Abdulaziz University, ( https://ror.org/04jt46d36) 11942 Alkharj, Saudi Arabia
                [6 ]School of Computing, Skyline University College, University City Sharjah, ( https://ror.org/05r7nbf33) 1797 Sharjah, UAE
                [7 ]Department of Software, Faculty of Artificial Intelligence and Software, Gachon University, ( https://ror.org/03ryywt80) Seongnam-si, 13120 Republic of Korea
                [8 ]Riphah School of Computing and Innovation, Faculty of Computing, Riphah International University, ( https://ror.org/02kdm5630) Lahore Campus, Lahore, 54000 Pakistan
                [9 ]GRID grid.416973.e, ISNI 0000 0004 0582 4340, AI Center for Precision Health, , Weill Cornell Medicine-Qatar, ; Doha, Qatar
                Article
                56478
                10.1038/s41598-024-56478-4
                10940612
                38486010
                6c7605df-8425-4f95-b57b-d74dbef7f94b
                © The Author(s) 2024

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 19 October 2023
                : 6 March 2024
                Funding
                Funded by: This research work is supported by Qatar National Library.
                Categories
                Article
                Custom metadata
                © Springer Nature Limited 2024

                Uncategorized
                artificial intelligence (ai),machine learning (ml),deep learning (dl),convolutional neural network (cnn),transfer learning (tl),vgg16,kidney-ureter-bladder (kub),kidney stones, explainable artificial intelligence (xai),layer-wise relevance propagation (lrp),kidney diseases,computer science

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