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      A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

      Proceedings of the National Academy of Sciences of the United States of America

      Base Sequence, Chromosome Mapping, DNA Transposable Elements, DNA, Bacterial, genetics, Enteritis, microbiology, pathology, Epithelium, Escherichia coli, pathogenicity, Genes, Bacterial, Molecular Sequence Data, Mutagenesis, Insertional, Restriction Mapping

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          Abstract

          Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.

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          7878036
          42580

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