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      A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.

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          Abstract

          Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.

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          Author and article information

          Journal
          Proc Natl Acad Sci U S A
          Proceedings of the National Academy of Sciences of the United States of America
          Proceedings of the National Academy of Sciences
          0027-8424
          0027-8424
          Feb 28 1995
          : 92
          : 5
          Affiliations
          [1 ] Department of Medicine, Department of Veterans Affairs Medical Center, Baltimore, MD.
          Article
          10.1073/pnas.92.5.1664
          42580
          7878036
          6d1d8556-1ce6-471f-ad00-496d1601f1ad
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