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      Reflections on Clinical and Statistical Use of the Penetration-Aspiration Scale

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          Abstract

          The 8-point Penetration-Aspiration Scale (PAS) was introduced to the field of dysphagia in 1996 and has become the standard method used by both clinicians and researchers to describe and measure the severity of airway invasion during swallowing. In this article, we review the properties of the scale and explore what has been learned over 20 years of use regarding the construct validity, ordinality, intervality, score distribution, and sensitivity of the PAS to change. We propose that a categorical revision of the PAS into four levels of increasing physiological severity would be appropriate. The article concludes with a discussion of common errors made in the statistical analysis of the PAS, proposing that frequency distributions and ordinal logistic regression approaches are most appropriate given the properties of the scale. A hypothetical dataset is included to illustrate both the problems and strengths of different statistical approaches.

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          Rank Transformations as a Bridge Between Parametric and Nonparametric Statistics

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            Role of oral bacteria in respiratory infection.

            An association between oral conditions such as periodontal disease and several respiratory conditions has been noted. For example, recent evidence has suggested a central role for the oral cavity in the process of respiratory infection. Oral periodontopathic bacteria can be aspirated into the lung to cause aspiration pneumonia. The teeth may also serve as a reservoir for respiratory pathogen colonization and subsequent nosocomial pneumonia. Typical respiratory pathogens have been shown to colonize the dental plaque of hospitalized intensive care and nursing home patients. Once established in the mouth, these pathogens may be aspirated into the lung to cause infection. Other epidemiologic studies have noted a relationship between poor oral hygiene or periodontal bone loss and chronic obstructive pulmonary disease. Several mechanisms are proposed to explain the potential role of oral bacteria in the pathogenesis of respiratory infection: 1. aspiration of oral pathogens (such as Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, etc.) into the lung to cause infection; 2. periodontal disease-associated enzymes in saliva may modify mucosal surfaces to promote adhesion and colonization by respiratory pathogens, which are then aspirated into the lung; 3. periodontal disease-associated enzymes may destroy salivary pellicles on pathogenic bacteria to hinder their clearance from the mucosal surface; and 4. cytokines originating from periodontal tissues may alter respiratory epithelium to promote infection by respiratory pathogens.
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              The effect of bolus viscosity on swallowing function in neurogenic dysphagia.

              To assess the pathophysiology and treatment of neurogenic dysphagia. 46 patients with brain damage, 46 with neurodegenerative diseases and eight healthy volunteers were studied by videofluoroscopy while swallowing 3-20 mL liquid (20.4 mPa s), nectar (274.4 mPa s) and pudding (3931.2 mPa s) boluses. Volunteers presented a safe and efficacious swallow, short swallow response ( or =0.33 mJ). Brain damage patients presented: (i) 21.6% aspiration of liquids, reduced by nectar (10.5%) and pudding (5.3%) viscosity (P or =806 ms) with a delay in laryngeal closure (> or =245 ms), and weak bolus propulsion forces (< or =0.20 mJ). Increasing viscosity did not affect timing of swallow response or bolus kinetic energy. Patients with neurogenic dysphagia presented high prevalence of videofluoroscopic signs of impaired safety and efficacy of swallow, and were at high risk of respiratory and nutritional complications. Impaired safety is associated with slow oropharyngeal reconfiguration and impaired efficacy with low bolus propulsion. Increasing bolus viscosity greatly improves swallowing function in neurological patients.
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                Author and article information

                Contributors
                416 597 3422 , Catriona.steele@uhn.ca
                Journal
                Dysphagia
                Dysphagia
                Dysphagia
                Springer US (New York )
                0179-051X
                1432-0460
                22 May 2017
                22 May 2017
                2017
                : 32
                : 5
                : 601-616
                Affiliations
                [1 ]ISNI 0000 0004 0474 0428, GRID grid.231844.8, Toronto Rehabilitation Institute, , University Health Network, ; 550 University Avenue, 12th Floor, Toronto, ON M5G 2A2 Canada
                [2 ]ISNI 0000 0001 2157 2938, GRID grid.17063.33, Rehabilitation Sciences Institute, , University of Toronto, ; 500 University Avenue, Suite 160, Toronto, ON M5G 1V7 Canada
                [3 ]The Analysis Factor, 430 W State St, Suite #204, Ithaca, NY 14850 USA
                Article
                9809
                10.1007/s00455-017-9809-z
                5608795
                28534064
                6e602b6e-9dc5-46db-b6af-a6f174e0edf2
                © The Author(s) 2017

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 24 December 2016
                : 11 May 2017
                Categories
                Review Article
                Custom metadata
                © Springer Science+Business Media, LLC 2017

                Otolaryngology
                deglutition,deglutition disorders,dysphagia,penetration-aspiration,videofluoroscopy,statistics

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