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      Shenfu injection: a review of pharmacological effects on cardiovascular diseases

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          Abstract

          Shenfu injection (SFI), composed of ginseng and aconite, is a Chinese patent developed from the classic traditional prescription Shenfu Decoction created more than 700 years ago. SFI has been widely used in China for over 30 years for treating cardiovascular diseases. The main components in it include ginsenosides and aconitum alkaloids. In recent years, the role of SFI in the treatment of cardiovascular diseases has attracted much attention. The pharmacological effects and therapeutic applications of SFI in cardiovascular diseases are summarized here, highlighting pharmacological features and potential mechanisms developments, confirming that SFI can play a role in multiple ways and is a promising drug for treating cardiovascular diseases.

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          Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

          Emelia Benjamin, Paul Muntner, Alvaro Alonso … (2019)
          Circulation, 139(10)
          Article 0 comments Cited 2306 times – based on 0 reviews     Review now
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            Toll-like Receptors and the Control of Immunity

            Katherine A Fitzgerald, Jonathan Kagan (2020)
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              Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics

              Xiaojun Feng, Antoni Sureda, Samineh Jafari … (2019)
              Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is an eminent component of traditional Chinese and Ayurvedic medicine for more than 2000 years. Recently, BBR has attracted much interest for its pharmacological actions in treating and/or managing CVMD. Recent discoveries of basic, translational and clinical studies have identified many novel molecular targets of BBR (such as AMPK, SIRT1, LDLR, PCSK9, and PTP1B) and provided novel evidences supporting the promising therapeutic potential of BBR to combat CVMD. Thus, this review provides a timely overview of the pharmacological properties and therapeutic application of BBR in CVMD, and underlines recent pharmacological advances which validate BBR as a promising lead drug against CVMD.
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                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Pharmacol
                Journal ID (iso-abbrev): Front Pharmacol
                Journal ID (publisher-id): Front. Pharmacol.
                Title: Frontiers in Pharmacology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 1663-9812
                Publication date (Electronic): 14 February 2024
                Publication date Collection: 2024
                Volume: 15
                Electronic Location Identifier: 1279584
                Affiliations
                [1] 1 State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine , Chengdu, China
                [2] 2 Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China , Chengdu, China
                [3] 3 Sichuan Nursing Vocational College , Chengdu, China
                Author notes

                Edited by: Yusof Kamisah, Faculty of Medicine Universiti Kebangaan Malaysia, Malaysia

                Reviewed by: Songqi Tang, Hainan Medical University, China

                Ahmad Khusairi Azemi, Universiti Malaysia Terengganu, Malaysia

                *Correspondence: Rong-Sheng Tong, tongrs@ 123456126.com ; Cheng Peng, pengchengchengdu@ 123456126.com
                Article
                Publisher ID: 1279584
                DOI: 10.3389/fphar.2024.1279584
                PMC ID: 10899515
                PubMed ID: 38420190
                SO-VID: 6f0c6ec6-f3c1-44e4-aeb1-bb260c89a76e
                Copyright © Copyright © 2024 Xu, Xie, Hu, Tong and Peng.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 18 August 2023
                Date accepted : 31 January 2024
                Funding
                The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Sichuan Province Natural Science Foundation Program (Grant NO. 24NSFSC0627); “Xinglin Scholars” Nursery Talent Special Program (grant number MPRC2023032).
                Categories
                Subject: Pharmacology
                Subject: Review
                Custom metadata
                section-at-acceptance Cardiovascular and Smooth Muscle Pharmacology

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: shenfu injection,cardiovascular disease,heart failure,pharmacology,tcm (traditional chinese medicine),clinical trial
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: shenfu injection, cardiovascular disease, heart failure, pharmacology, tcm (traditional chinese medicine), clinical trial

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