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      Changes in dorsolateral prefrontal connectivity after rTMS in treatment-resistant depression: a brain perfusion SPECT study.

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          Abstract

          Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and safe alternative to electroconvulsive therapy for treatment-resistant depression (TRD). After rTMS, changes in brain SPECT perfusion have been remotely identified within medial temporal limbic areas, while no local effects have been found within the left dorsolateral prefrontal cortex (DLPFC)-i.e. under the coil. Functional changes in connectivity may underlie these remote effects. Interestingly, functional connectivity has been recently investigated using perfusion SPECT, and abnormalities identified in TRD patients. The aim of the present study is to evaluate perfusion and connectivity SPECT changes in TRD patients after rTMS of the left DLPFC. We hypothesize that changes in DLPFC networks may explain remote hypoperfusions found after rTMS.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Eur. J. Nucl. Med. Mol. Imaging
          Title: European journal of nuclear medicine and molecular imaging
          Publisher: Springer Nature
          ISSN (Electronic): 1619-7089
          ISSN (Print): 1619-7070
          Publication date (Electronic): Jun 2017
          Volume: 44
          Issue: 6
          Affiliations
          [1 ] Department of Psychiatry, La Conception University Hospital, 13005, Marseille, France.
          [2 ] EA 3279 - Self-perceived Health Assessment Research Unit, Aix-Marseille Univ, 13005, Marseille, France.
          [3 ] Service Central de Biophysique et Médecine Nucléaire, Hôpital de la Timone, APHM, 264 rue Saint Pierre, 13005, Marseille, France.
          [4 ] Department of Nuclear Medicine & Nancyclotep Imaging Platform, 54000, Nancy, France.
          [5 ] IADI, INSERM U947, 54000, Nancy, France.
          [6 ] Department of Public Health, Assistance Publique - Hôpitaux de Marseille, Marseille, France.
          [7 ] Service Central de Biophysique et Médecine Nucléaire, Hôpital de la Timone, APHM, 264 rue Saint Pierre, 13005, Marseille, France. eric.guedj@ap-hm.fr.
          [8 ] Aix-Marseille Univ, INT, CNRS UMR 7289, 13005, Marseille, France. eric.guedj@ap-hm.fr.
          [9 ] Aix-Marseille Univ, CERIMED, 13005, Marseille, France. eric.guedj@ap-hm.fr.
          Article
          Publisher Item ID: 10.1007/s00259-017-3640-5
          DOI: 10.1007/s00259-017-3640-5
          PubMed ID: 28154905
          SO-VID: 7097831d-9f7a-4060-b7f3-f0de6c14d248
          History

          Keywords: Connectivity,Repetitive transcranial magnetic stimulation (rTMS),SPM,Single-photon emission computed tomography (SPECT),Treatment-resistant depression
          Data availability:
          Keywords: Connectivity, Repetitive transcranial magnetic stimulation (rTMS), SPM, Single-photon emission computed tomography (SPECT), Treatment-resistant depression

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