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      Double P53 point mutation in extramedullary blast crisis of chronic myelogenous leukemia.

      1 , , , ,
      Leukemia & lymphoma
      Informa UK Limited

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          Abstract

          A patient with Philadelphia-positive chronic myelogenous leukemia (CML) evolved in extramedullary blast crisis, was studied for the presence of alterations of the P53 tumor suppressor gene in the different stages of disease progression. No P53 gene aberrations were detected during the chronic and accelerated phases. Two identical missense point mutations, involving codons 249 and 281 and leading to the amino acid substitutions Arg-Ser and Thy-Asp, were identified in cells of an extramedullary mass and then in peripheral blood blast crisis cells. The data indicate that the medullary and extramedullary blast cells belong to the same cellular clone. They also strongly suggest that in this case, the alteration of P53 gene is strictly related to the progression of the disease, although this mechanism is certainly neither the only nor the most frequent molecular event leading to the acute phase.

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          Author and article information

          Journal
          Leuk Lymphoma
          Leukemia & lymphoma
          Informa UK Limited
          1042-8194
          1026-8022
          Dec 1994
          : 16
          : 1-2
          Affiliations
          [1 ] Center for Experimental Hematology, University of Modena, Italy.
          Article
          10.3109/10428199409114155
          7696924
          7099d8a4-888d-45ab-bf84-6fabb59f3efb
          History

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